PPARγ signaling and metabolism: the good, the bad and the future
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Additional excerpts
...Mario F. Muñoz was supported by Consejeria de Economı́a, Innovacion y Ciencia de la Junta de Andalucia (Spain) postdoctoral fellowship (P10-CTS-6494)....
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1,746 citations
Cites background from "PPARγ signaling and metabolism: the..."
..., 2003), but TZD use causes weight gain, not weight loss (Ahmadian et al., 2013)....
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...Thiazolidinediones have been reported to increase the browning of white fat (Petrovic et al., 2010; Qiang et al., 2012; Teruel et al., 2003), but TZD use causes weight gain, not weight loss (Ahmadian et al., 2013)....
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...Unfortunately, the clinical utility of TZDs has been limited by their unfavorable side effect profile, including fluid retention, osteoporosis, and (possibly) increased risk of cardiovascular events (Ahmadian et al., 2013)....
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593 citations
Cites background from "PPARγ signaling and metabolism: the..."
...PPARg activation broadly inhibits proinflammatory pathways, leading to decreased ATM content, increased adipose tissue eosinophil numbers, and increased differentiation of anti-inflammatory Treg cells (Ahmadian et al., 2013; Hamaguchi and Sakaguchi, 2012)....
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References
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