PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation.
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...Nevertheless it is impossible to adequately address PPAR functionality in obesity within the current review and this topic was reviewed very comprehensively elsewhere (Stienstra et al., 2007; Varga et al., 2011)....
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"PPARs are a unique set of fatty aci..." refers background in this paper
...The alternative explanation suggests that chronic caloric overload initiates an inflammatory response that is originated in the adipose tissue [15,16]....
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"PPARs are a unique set of fatty aci..." refers background in this paper
...Typically, chronic inflammatory reactions develop gradually from an acute reaction if the host is not able to eliminate the inflammatory inducer (for a review of inflammation, see [8])....
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"PPARs are a unique set of fatty aci..." refers background in this paper
...This suggested that liganded PPARγ acted via transrepression of other transcription factors [76]....
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"PPARs are a unique set of fatty aci..." refers background in this paper
...The inflammatory reaction make adipocytes and immune cells residing in the adipose tissue produce cytokines and adipokines (such as tumor necrosis alpha (TNFα)) that could lead to impaired glucose tolerance in remote tissues of the body [17]....
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