Predicting radiation pneumonitis after chemoradiation therapy for lung cancer: an international individual patient data meta-analysis.
Citations
1,498 citations
Cites background from "Predicting radiation pneumonitis af..."
...Moreover, in a recent metaanalysis on risk factors for symptomatic radiation pneumonitis, elderly patients who received carboplatin–paclitaxel chemotherapy were at highest risk [42]....
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Cites background from "Predicting radiation pneumonitis af..."
...[22] found that the PC regimen was an independent predictive factor of RP (OR of PC relative to EP1⁄4 3....
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141 citations
Cites background or methods from "Predicting radiation pneumonitis af..."
...Recursive partitioning analysis (RPA) was performed incorporating significant predictors of esophagitis identified from multivariable logistic regression as described previously (6) and was used to create risk groups....
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...Given that all patients in this meta-analysis received concurrent chemotherapy, this could not be assessed directly, although the different chemotherapy agents did not seem to affect RE risk, as they appear to do with pneumonitis risk (6)....
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...The full search strategy, including electronic searches and hand searches for data published in abstract form or unpublished, has been reported previously (6)....
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...The first substudy examining predictors of radiation pneumonitis was recently reported (6)....
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References
892 citations
584 citations
"Predicting radiation pneumonitis af..." refers background in this paper
...Lung volume receiving 20 Gy (%) 819 30 (7-78)...
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...In the context of palliative chemotherapy, a meta-analysis has demonstrated that cisplatin is a more active first-line treatment against NSCLC than carboplatin: cisplatin achieves superior response rates, and in some subgroups it improved survival (18)....
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...15) Lung volume receiving 5 Gy (%) 404 38 (14-100)...
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393 citations
"Predicting radiation pneumonitis af..." refers background or result in this paper
...Many earlier studies included heterogeneous groups of patients not necessarily applicable to modern NSCLC treatment (ie, patients treated without chemotherapy, with older radiation therapy techniques, or for nonlung malignancies); correlations between baseline variables and pneumonitis outcomes are generally weak; and results are rarely validated in separate datasets (2, 3)....
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...Recursive partitioning analysis of radiation pneumonitis risk in p non-small-cell lung cancer (NSCLC)....
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...Several studies have identified relationships between baseline patient-related or dose-related factors and rates of radiation pneumonitis (2), but predictive models have not been widely implemented for several reasons....
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...The onset of radiation pneumonitis after radical CCRT for NSCLC is associated with significant morbidity and occasionally mortality....
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...The goal of this first component of the STRIPE project was to develop and validate a predictive model for radiation pneumonitis in patients receiving modern CCRT for the treatment of locally advanced NSCLC....
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314 citations
"Predicting radiation pneumonitis af..." refers background in this paper
...Lung volume receiving 20 Gy (%) 819 30 (7-78)...
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...Data were available on 836 patients from 12 different sources (Table 1), all previously reported in whole or in part, including 10 articles (3, 5-13) and 2 abstracts (14, 15), some of which provided updated datasets....
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241 citations
"Predicting radiation pneumonitis af..." refers methods in this paper
...Lung volume receiving 20 Gy (%) 819 30 (7-78)...
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...The carboplatin/ paclitaxel CCRT combination has been compared in a 3-arm randomized noninferiority study against irinotecan/carboplatin and mitomycin/vindesine/cisplatin, with the latter considered the “standard” arm (19)....
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...15) Lung volume receiving 5 Gy (%) 404 38 (14-100)...
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