Predictors for Symptomatic Intracranial Hemorrhage After Endovascular Treatment of Acute Ischemic Stroke.
Yonggang Hao,Dong Yang,Huaiming Wang,Wenjie Zi,Meng Zhang,Yu Geng,Zhiming Zhou,Wei Wang,Haowen Xu,Xiguang Tian,Penghua Lv,Yuxiu Liu,Yunyun Xiong,Xinfeng Liu,Gelin Xu +14 more
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TLDR
Incidence of SICH after thrombectomy is higher in Asian patients with acute ischemic stroke, and Cardioembolic stroke, poor collateral circulation, delayed endovascular treatment, multiple passes with stent retriever device, lower pretreatment Alberta Stroke Program Early Computed Tomography Score, higher baseline neutrophil ratio may increase the risk of Sich.Abstract:
Background and Purpose—Symptomatic intracranial hemorrhage (SICH) pose a major safety concern for endovascular treatment of acute ischemic stroke. This study aimed to evaluate the risk and related ...read more
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Direct mechanical thrombectomy in tPA-ineligible and -eligible patients versus the bridging approach: a meta-analysis.
Johannes Kaesmacher,Pasquale Mordasini,Marcel Arnold,Elena López-Cancio,Neus Cerdà,Tobias Boeckh-Behrens,Justus F Kleine,Mayank Goyal,Michael D. Hill,Vitor Mendes Pereira,Jeffrey L. Saver,Jan Gralla,Urs Fischer +12 more
TL;DR: The data suggest that dMTE may offer comparable safety and efficacy as compared with IVT+MTE when considering studies with lower selection bias, and the conduct of randomized-controlled clinical trials seems justified.
Journal ArticleDOI
Low-Dose Tirofiban Improves Functional Outcome in Acute Ischemic Stroke Patients Treated With Endovascular Thrombectomy
Wenbo Zhao,Ruiwen Che,Shuyi Shang,Wu Chuanjie,Chuanhui Li,Longfei Wu,Jian Chen,Jiangang Duan,Haiqing Song,Hongqi Zhang,Feng Ling,Wang Yuping,David S Liebeskind,Wuwei Feng,Xunming Ji +14 more
TL;DR: In patients with AIS undergoing ET, tirofiban is not associated with higher sICH, it seems to lead to lower odds of deaths and better odds of long-term functional independence, and further investigations are needed to determine the efficacy of tiroFiban in preventing early reocclusion, the underlying mechanisms, and its optimal treatment protocol.
Journal ArticleDOI
Mechanical Thrombectomy in Ischemic Stroke Patients With Alberta Stroke Program Early Computed Tomography Score 0-5.
Johannes Kaesmacher,Panagiotis Chaloulos-Iakovidis,Leonidas Panos,Pasquale Mordasini,Patrik Michel,Steven D. Hajdu,Marc Ribo,Manuel Requena,Christian Maegerlein,Benjamin Friedrich,Vincent Costalat,Amel Benali,L. Pierot,Matthias Gawlitza,Joanna D. Schaafsma,Vitor Mendes Pereira,Jan Gralla,Urs Fischer +17 more
TL;DR: In patients presenting with ASPECTS 0–5, who were treated with mechanical thrombectomy, successful reperfusion was beneficial without increasing the risk of symptomatic intracerebral hemorrhage.
Journal ArticleDOI
Results From DEFUSE 3: Good Collaterals Are Associated With Reduced Ischemic Core Growth but Not Neurologic Outcome
Adam de Havenon,Michael Mlynash,May Kim-Tenser,Maarten G Lansberg,Thalabe Leslie-Mazwi,Soren Christensen,Ryan A McTaggart,Matthew D Alexander,Gregory W. Albers,Joseph P. Broderick,Michael P. Marks,Jeremy J Heit +11 more
TL;DR: Good leptomeningeal collaterals on single phase computed tomography angiography were not predictive of functional independence or death and did not impact the treatment effect of endovascular thrombectomy in the late therapeutic window.
References
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Journal ArticleDOI
Guidelines for the Early Management of Patients With Acute Ischemic Stroke A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
William J. Powers,Alejandro A. Rabinstein,Teri Ackerson,Opeolu Adeoye,Nicholas C. Bambakidis,Kyra J. Becker,José Biller,Michael D. Brown,Bart M. Demaerschalk,Brian L. Hoh,Edward C. Jauch,Chelsea S. Kidwell,Thabele M Leslie-Mazwi,Bruce Ovbiagele,Phillip A. Scott,Kevin N. Sheth,Andrew M. Southerland,Deborah V. Summers,David L. Tirschwell +18 more
TL;DR: These guidelines supersede the prior 2007 guidelines and 2009 updates and support the overarching concept of stroke systems of care and detail aspects of stroke care from patient recognition; emergency medical services activation, transport, and triage; through the initial hours in the emergency department and stroke unit.
Journal ArticleDOI
A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke
Debbie Beumer,Debbie Beumer,Julie Staals,Jeannette Hofmeijer,Jelis Boiten,J. De Vries,Omid S. Eshghi,Koos Keizer,R. van den Berg,A. van der Lugt,Abstr Act +10 more
TL;DR: In patients with acute ischemic stroke caused by a proximal intracranial occlusion of the anterior circulation, intraarterial treatment administered within 6 hours after stroke onset was effective and safe.
Journal ArticleDOI
Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials
Mayank Goyal,Bijoy K Menon,Wim H. van Zwam,Diederik W.J. Dippel,Peter Mitchell,Andrew M. Demchuk,Antoni Dávalos,Charles B. L. M. Majoie,Aad van der Lugt,Maria Angeles De Miquel,Geoffrey A. Donnan,Yvo B.W.E.M. Roos,Alain Bonafe,Reza Jahan,Hans-Christoph Diener,Lucie A. van den Berg,Elad I. Levy,Olvert A. Berkhemer,Vitor Mendes Pereira,Jeremy L. Rempel,Mónica Millán,Stephen M. Davis,Daniel Roy,John Thornton,Luis San Roman,Marc Ribo,Debbie Beumer,Bruce Stouch,Scott Brown,Bruce C.V. Campbell,Robert J. van Oostenbrugge,Jeffrey L. Saver,Michael D. Hill,Tudor G Jovin +33 more
TL;DR: Endovascular thrombectomy is of benefit to most patients with acute ischaemic stroke caused by occlusion of the proximal anterior circulation, irrespective of patient characteristics or geographical location, and will have global implications on structuring systems of care to provide timely treatment.
Journal ArticleDOI
Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke
Mayank Goyal,Muneer Eesa,John Thornton,Denis-Claude Roy,Dar Dowlatshahi,Ashfaq Shuaib,D. Tampieri,David Williams,H. Choe,Brian T. Jankowitz,Michael Kelly,Guillermo Linares,Jai Jai Shiva Shankar,Alain Weill,Suresh Subramaniam,Abstr Act +15 more
TL;DR: In this paper, the authors evaluated rapid endovascular treatment in addition to standard care in patients with acute ischemic stroke with a small infarct core, a proximal intracranial arterial occlusion, and moderate-to-good collateral circulation.
Journal ArticleDOI
Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection
Bruce C.V. Campbell,Leonid Churilov,Nawaf Yassi,Bernard Yan,M. Brooks,F. Miteff,Martin Krause,M. Priglinger,Timothy Ang,Rebecca Scroop,Ben McGuinness,Tissa Wijeratne,Winston Chong,Monica S Badve,H. Rice,L. de Villiers,Henry Ma,Abstr Act +17 more
TL;DR: In patients with ischemic stroke with a proximal cerebral arterial occlusion and salvageable tissue on CT perfusion imaging, early thrombectomy with the Solitaire FR stent retriever, as compared with alteplase alone, improved reperfusion, early neurologic recovery, and functional outcome.
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