Preliminary Single-Center Canadian Experience of Human Normothermic Ex Vivo Liver Perfusion: Results of a Clinical Trial.
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Cites background from "Preliminary Single-Center Canadian ..."
...Although there have been case reports and small series of liver transplants following ex situ normothermic perfusion (4-8), there are as yet no validated criteria predicting liver viability....
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Cites result from "Preliminary Single-Center Canadian ..."
...1B), when compared to previous published values from DCD livers during end-ischemic normothermic perfusion.(2,21) Second, the release of mitochondrial flavin, for example, FMN, occurred independently from the release of cytosolic hepatocellular enzymes, for example, AST, ALT, or LDH, consistent with a mitochondrial origin of FMN (Fig....
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"Preliminary Single-Center Canadian ..." refers background in this paper
...7 days; (iii) EAD incidence in the first 7 days (24); (iv) liver biochemistry in serum on days 1–7, 10, and 30; (v) major complications defined by a ClavienDindo score ≥3 (25); (vi) patient and graft survival at 6 mo; and (vii) biliary...
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816 citations
"Preliminary Single-Center Canadian ..." refers background in this paper
...7 days; (iii) EAD incidence in the first 7 days (24); (iv) liver biochemistry in serum on days 1–7, 10, and 30; (v) major complications defined by a ClavienDindo score ≥3 (25); (vi) patient and graft survival at 6 mo; and (vii) biliary...
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"Preliminary Single-Center Canadian ..." refers background or methods or result in this paper
...) was completed in the United Kingdom, demonstrating feasibility and safety (23)....
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...Furthermore, in contrast to Ravikumar et al and Selzner et al, we did not observe significant differences in early recipient transaminases between NMP and SCS preserved grafts (23,30)....
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...Ravikumar et al showed that NMP livers had lower median peak aspartate aminotransferase (AST) levels compared with matched SCS controls, suggesting enhanced hepatic protection....
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...Normothermic machine perfusion Livers allocated to the intervention group were preserved using the NMP system (Organ Ox metra), as described recently (Figure S2) (23)....
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...All perfusate additives were otherwise identical to those described by Ravikumar et al (23)....
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298 citations