SA Fam Pract 2007:49(3)
22
CPD Article
loss but still does not make this a viable
option in the long term. It could however
be used to predict the effect of surgical
oophorectomy.
21,22,23
Danazol
Danazol does improve the symptoms
but only once high enough dosages
are used to suppress ovulation. Unfor-
tunately the androgenic side effects are
too severe at these dosages for most
patients.
Spironolactone
This steroid like diuretic should have the
best likelihood to be effective but results
of trials are at best ambiguous.
Exercise
It is difficult to investigate this option in a
blinded manner but trials and observa-
tional data suggest a beneficial effect.
Exercise should be recommended.
Calcium
There are studies that show a beneficial
response on calcium supplementation if
600mg twice daily is used. Other stud-
ies show a dose related association
between intake and severity of symp-
toms.
24
Other Supplements
The response on vitamin B6 is at best not
dramatic but it might well be worth try-
ing.
25
Magnesium supplementation has
even less convincing scientific evidence
but small trials have described modest
improvements. Vitamin E supplementa-
tion at 400IU per day was described in
small studies to improve the physical
and affective symptoms.
Evening Primrose oil, gingko biloba
and essential free fatty acids really have
no evidence to show their efficacy and
progesterone has been shown not to
work.
SUGGESTED APPROACH TO MAN-
AGEMENT:
In patients where the diagnosis has
been established and the woman is
symptom free in the follicular phase,
it would be important to quantify her
symptoms. If the situation is manage-
able the patient should be advised to
exercise in a scheduled program with
significant intensity. Vitamin B6 should
probably be offered as it might work and
is harmless as long as doses not more
than 100mg per day is used.
If distress is judged to be severe
SRI’s should be offered. About 30%
of patients will not respond to SRI’s and
it might be worth while increasing the
dose, changing to a 2
nd
SRI or switching
from luteal phase therapy to continuous
therapy. A few patients will have signifi-
cant side effects such as nausea, head-
ache, poor libido and anorgasmia.
Drosperinone containing contracep-
tives should frequently be used and in
recalcitrant cases alprazolam, spirono-
lactone and calcium supplements might
offer some relief. As an absolute last
resort and when GnRH has been suc-
cessful in alleviating symptoms removal
of the uterus and ovaries should be con-
templated.
See CPD Questionnaire, page 39
P This article has been peer reviewed
References:
1. Bailey, JW, Cohen, LS. Prevalence of
mood and anxiety disorders in women who
seek treatment for premenstrual syndrome.
J Womens Health Gend Based Med 1999;
8:1181.
2. Steiner, M, Born, L. Diagnosis and treat-
ment of premenstrual dysphoric disorder:
an update. Int Clin Psychopharmacol
2000; 15 Suppl 3:S5.
3. Amercian Psychiatric Association. Diag-
nostic and Statistical Manual Edition IV,
American Psychiatric Association, Wash-
ington, DC 1994, p715.
4. Halbreich, W, Endicott, J, Lesser J. The
clinical diagnosis and classification of pre-
menstrual changes. Can J Psychiatr 1985;
30:489.
5. Schmidt, PJ, Nieman, LK, Danaceau< MA,
et al. Differential behavioral effects of go-
nadal steroids in women with and in those
without premenstrual syndrome. N Engl J
Med 1998; 338:209.
6. Wardlaw, SL, Thoron, L, Frantz, AG. Ef-
fects of sex steroids on brain beta-endor-
phin. Brain Res 1982; 245:327
7. Giannini, AJ, Martin, DM, Turner, CE. Beta-
endorphin decline in late luteal phase dys-
phoric disorder. Int J Psychiatry Med 1990;
20:279.
8. Taylor, DL, Matthew, RH, Ho, BT, et al.
Serotonin levels and platelet uptake during
premenstrual tension. Neuropsychobiol-
ogy 1984; 12:16.
9. Chuong, CJ, Coulam, CB, Koo, PC, et al.
Neuropeptide levels in premenstrual syn-
drome. Fertil Steril 1985 ; 44 :760.
10. Rapkin, AJ, Edelmuth, E, Chang, LC, et
al. Whole-blood serotonin in premenstrual
syndrome. Obstet Gynecol 1987; 70:533.
11. Beck, LE, Gevirtz, R, Mortola, JF. The
predictive role of psychosocial stress on
symptom severity in premenstrual syn-
drome. Psychosom Med 1990; 52:536.
12. Fontana, AM, Palfai, TG. Psychosocial fac-
tors in premenstrual dysphoria: Stressors,
appraisal, and coping processes. J Psy-
chosom Res 1994; 38:557.
13. Dimmock, PW, Wyatt, KM, Jones, PW,
O’Brien, PM. Efficacy of selective sero-
tonin-reuptake inhibitors in premenstrual
syndrome: a systematic review. Lancet
2000; 356:1131.
14. Wyatt, KM, Dimmock, PW, O’Brien, PM.
Selective serotonin reuptake inhibitors for
premenstrual syndrome. Cochrane Data-
base Syst Rev 2002; :CD001396.
15. Cohen, LS, Miner, C, Brown, EW, et al. Pre-
menstrual daily fluoxetine for premenstrual
dysphoric disorder: a placebo-controlled,
clinical trial using computerized diaries.
Obstet Gynecol 2002; 100:435
16. Smith, S, Reinhart, J, Ruddock, V, Schiff,
I. Treatment of premenstrual syndrome
with alprazolam: Results of a double blind,
placebo controlled, randomized crossover
clinical trial. Obstet Gynecol 1987; 70:37.
17. Harrison, WM, Endicott, J, Nee, J. Treat-
ment of premenstrual dysphoria with
alprazolam. A controlled study. Arch Gen
Psychiatry 1990; 47:270
18. Berger, CP, Presser, B. Alprazolam in the
treatment of two subsamples of patients
with late luteal phase dysphoric disorder:
a double-blind, placebo-controlled cross-
over study. Obstet Gynecol 1994; 84:379
19. Yonkers, KA, Brown, C, Pearlstein, TB,
Foegh, M. Efficacy of a New Low-Dose
Oral Contraceptive With Drospirenone in
Premenstrual Dysphoric Disorder. Obstet
Gynecol 2005; 106:492.
20. Pearlstein, TB, Bachmann, GA, Zacur, HA,
Yonkers, KA. Treatment of premenstrual
dysphoric disorder with a new drospire-
none-containing oral contraceptive formu-
lation. Contraception 2005; 72:414.
21. Freeman, EW, Sondheimer, SJ, Rickels, K.
Gonadotropin-releasing hormone agonist
in the treatment of premenstrual symptoms
with and without ongoing dysphoria: a con-
trolled study. Psychopharmacol Bull 1997;
33:303.
22. Brown, CS, Ling, FW, Andersen, RN, et al.
Efficacy of depot leuprolide in premenstrual
syndrome: Effect of symptoms severity and
type in a controlled trial. Obstet Gynecol
1994; 84:779.
23. Berger, CP, Presser, B. Alprazolam in the
treatment of two subsamples of patients
with late luteal phase dysphoric disorder:
a double-blind, placebo-controlled cross-
over study. Obstet Gynecol 1994; 84:379.
24. Thys-Jacobs, S, Starkey, P, Bernstein, D,
Tian, J. Calcium carbonate and the pre-
menstrual syndrome: effects on premen-
strual and menstrual symptoms. Premen-
strual Syndrome Study Group. Am J Obstet
Gynecol 1998; 179:444.
25. Wyatt, KM, Dimmock, PW, Jones, PW,
Shaughn O’Brien, PM. Efficacy of vitamin
B-6 in the treatment of premenstrual syn-
drome: Systematic review. BMJ 1999; 318:
1375.