Preoperative Chemoradiotherapy for Esophageal or Junctional Cancer
Citations
262 citations
Cites background or result from "Preoperative Chemoradiotherapy for ..."
...significantly improved OS and DFS compared to surgery alone in patients with resectable (T2-T3,N0-1,M0) esophageal or EGJ cancers (n = 366; 75% had adenocarcinoma and 23% had SCC).(153) Median OS was 49...
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...008), the histologic subtype was not a prognostic factor for survival.(153) After a minimum follow-up of 24 months, the overall rate of recurrence was 35% in the preoperative chemoradiation arm compared to 58% in the surgery alone arm....
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...Preoperative chemoradiation is the preferred approach for localized resectable disease.(153) Perioperative chemotherapy or preoperative chemotherapy are alternative options for adenocarcinoma of the thoracic esophagus or EGJ....
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235 citations
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207 citations
Cites background or methods or result from "Preoperative Chemoradiotherapy for ..."
...However, proofs of a clear survival benefit for patients with esophageal adenocarcinoma are missing because successfully completed randomized controlled trials (RCT) comparing perioperative chemotherapy with neoadjuvant chemoradiation are missing thus far and indirect comparisons are based on pooled and more or less heterogeneous patient cohorts including esophageal adenocarcinoma and gastric cancer [6, 7]....
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...Although no results from RCTs and/or phase III studies have been published for perioperative chemotherapy with FLOT thus far, the promising results from phase II have made FLOT the protocol of choice for perioperative treatment of esophageal adenocarcinoma and gastric cancer in many specialized German cancer centers....
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...As neoadjuvant chemoradiation plus surgery has already been proven by an RCT [3] to be superior to surgery alone, it serves as the control group and no surgery alone group is added....
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...As nowadays perioperative chemotherapy is extensively and successfully applied in clinical practice in patients with esophageal adenocarcinoma, there is an obvious need to obtain evidence from a multicenter RCT....
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...Apart from a single RCT which compared neoadjuvant chemoradiation with neoadjuvant chemotherapy (carried out between 2000–2005 and terminated prematurely due to poor accrual without showing significant differences concerning survival), this is the only comparative analysis on neoadjuvant chemoradiation versus perioperative chemotherapy in patients with esophageal adenocarcinoma [11]....
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203 citations
References
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Additional excerpts
...Esophagogastric junction 39 (22) 49 (26)...
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...Anastomotic leakage** 36/161 (22) 48/161 (30)...
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