Journal ArticleDOI
Preoperative monocyte-to-lymphocyte ratio predicts recurrence in gastrointestinal stromal tumors
Ferdinando Carlo Maria Cananzi,Eleonora Maddalena Minerva,Laura Samà,Laura Ruspi,Federico Sicoli,Lorenzo Conti,Uberto Fumagalli Romario,Vittorio Quagliuolo +7 more
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TLDR
Several inflammation markers were found to have a prognostic value in cancer and the significance of preoperative white cell ratios in determining gastrointestinal stromal tumors outcome was investigated.Abstract:
BACKGROUND AND OBJECTIVES Several inflammation markers were found to have a prognostic value in cancer. We investigated the significance of preoperative white cell ratios in determining gastrointestinal stromal tumors (GISTs) outcome. METHODS Clinicopathological features of patients who underwent surgery for GIST were reviewed. The following peripheral blood inflammation markers were calculated: neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), neutrophil-white blood cell ratio (NWR), lymphocyte-white cell ratio (LWR), monocyte-white cell ratio (MWR), and platelet-white cell ratio (PWR). RESULTS We analyzed 127 patients. Three- and five-year disease-free survival (DFS) were 89.7% and 86.9%, respectively. The univariate analysis selected tumor diameter (P = 0.003), gastric location ( P = 0.024), cell type ( P = 0.024), mitosis ( P < 0.001), MLR ( P = 0.014), NLR ( P = 0.016), and PLR ( P = 0.001) as the factors associated to DFS. The independent prognostic factors for DFS were mitosis ( P = 0.001), NLR ( P = 0.015), MLR ( P = 0.015), and PLR ( P = 0.031), with MLR showing the highest statistical significance and hazard ratio (HR) value. MLR, NLR, and PLR were the only prognostic factors in the subgroup of patients with moderate to high Miettinen's risk class. A high value of MLR was associated with reduced DFS. CONCLUSION MLR, NLR, and PLR are independent prognostic factors for DFS in GISTs. We first demonstrated the role of MLR as a predictor of recurrence in GIST. Its inclusion into clinical management may improve the recurrence estimation.read more
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Monocyte lymphocyte ratio As a predictor of Diabetic Kidney Injury in type 2 Diabetes mellitus; The MADKID Study
Mehmet Zahid Kocak,Gulali Aktas,Tuba Taslamacioglu Duman,Burcin M. Atak,Ozge Kurtkulagi,Hikmet Tekce,Satilmis Bilgin,Betül Alaca +7 more
TL;DR: It is suggested that MLR could serve as a predictive and effective marker for DKI in diabetic subjects due to its strong correlation with MA and inexpensive and readily available nature.
Journal ArticleDOI
Monocyte-to-lymphocyte ratio as a prognostic factor in peripheral whole blood samples of colorectal cancer patients.
Katarzyna Jakubowska,Mariusz Koda,Małgorzata Grudzińska,Luiza Kanczuga-Koda,Waldemar Famulski +4 more
TL;DR: The postoperative MLR in whole blood samples can be used as an independent prognostic factor in patients diagnosed with colorectal cancer and was positively associated with histological type of cancer and percentage of the mucinous component.
Journal ArticleDOI
Prognostic Significance of Preoperative Systemic Cellular Inflammatory Markers in Gliomas: A Systematic Review and Meta-Analysis
TL;DR: This meta‐analysis indicates the NLR, RDW, and PNI rather than PLR and LMR are the independent index for predicting the OS of gliomas.
Journal ArticleDOI
Neutrophil-to-Lymphocyte Ratio (NLR) and Monocyte-to-Lymphocyte Ratio (MLR) Predict Clinical Outcome in Patients with Stage IIB Cervical Cancer.
TL;DR: In this paper, the authors determined the prognostic value of platelet-to-lymphocyte ratio (PLR), neutrophil-threshold-based ratio (NLR), monocyte-tolymphocytes ratio (MLR), basophil-to]-threshold ratio (BLR), and systemic inflammation response index (SIRI) as inflammatory indexes in patients with stage IIB cervical cancer.
Journal ArticleDOI
Prognostic value of preoperative lymphocyte-related systemic inflammatory biomarkers in upper tract urothelial carcinoma patients treated with radical nephroureterectomy: a systematic review and meta-analysis
TL;DR: Elevated preoperative NLR, PLR, and MLR were significantly associated with worse OS, CSS, DFS/RFS/MFS, and PFS in the UTUC patients undergoing RNU and poor prognosis in patients with surgically treated UTUC.
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