Preparation and In Vitro Evaluation of Aspartic/Alginic Acid Based Semi-Interpenetrating Network Hydrogels for Controlled Release of Ibuprofen.
TL;DR: In this article, different combinations of polymers, aspartic acid, alginic acid (AL), and monomer acrylic acid (AA), were crosslinked in the presence of an initiator ammonium peroxodisulfate (APS) and cross-linker ethylene glycol dimethacrylate (EGDMA) to develop as partic acid/alginic acids-co-poly(acrylic acid) (ASP/ALPAA) (semi-interpenetrating polymer network (SIPN)) hydrogels by
Abstract: Different combinations of polymers, aspartic acid (ASP), alginic acid (AL), and monomer acrylic acid (AA) were crosslinked in the presence of an initiator ammonium peroxodisulfate (APS) and cross-linker ethylene glycol dimethacrylate (EGDMA) to develop aspartic acid/alginic acid-co-poly(acrylic acid) (ASP/ALPAA) (semi-interpenetrating polymer network (SIPN)) hydrogels by the free radical polymerization technique for the controlled delivery of ibuprofen (IBP). Various studies such as dynamic swelling studies, drug loading, in vitro drug release and sol−gel analysis were carried out for the hydrogels. Higher swelling was observed at higher pH 7.4 as compared to lower pH 1.2, due to the presence of carboxylic groups of polymers and the monomer. Hence, pH-dependent swelling was exhibited by the developed hydrogels which led to a pH-dependent drug release and vice versa. The structural properties of the hydrogels were assessed by FTIR, PXRD, TGA, DSC, and SEM which confirmed the fabrication and stability of the developed structure. FTIR analysis revealed the reaction of both polymers with the monomer during the polymerization process and confirmed the overlapping of the monomer on the backbone of the both polymers. The disappearance of high intense crystalline peaks and the encapsulation of the drug by the hydrogel network was confirmed by PXRD. TGA and DSC showed that the developed hydrogels were thermally more stable than their basic ingredients. Similarly, the surface morphology of the hydrogels was analyzed by SEM and showed a smooth surface with few pores. Conclusively, ASP/ALPAA hydrogels have the potential to deliver IBP for a long period of time in a controlled way.
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TL;DR: It is concluded that GA crosslinked 5-FU loaded AM and AA based hydrogels would be a potential pH-sensitive oral controlled colon drug delivery carrier.
Abstract: This project aims to synthesize and characterize the pH-sensitive controlled release of 5-fluorouracil (5-FU) loaded hydrogels (5-FULH) by polymerization of acrylamide (AM) and acrylic acid (AA) in the presence of glutaraldehyde (GA) as a crosslinker with ammonium persulphate as an initiator. The formulation's code is named according to acrylamide (A1, A2, A3), acrylic acid (B1, B2, B3) and glutaraldehyde (C1, C2, C3). The optimized formulations were exposed to various physicochemical tests, namely swelling, diffusion, porosity, sol gel analysis, and attenuated total reflection-Fourier transform infrared (ATR-FTIR). These 5-FULH were subjected to kinetic models for drug release data. The 5-FU were shown to be soluble in distilled water and phosphate buffer media at pH 7.4, and sparingly soluble in an acidic media at pH 1.2. The ATR-FTIR data confirmed that the 5-FU have no interaction with other ingredients. The lowest dynamic (0.98 ± 0.04% to 1.90 ± 0.03%; 1.65 ± 0.01% to 6.88 ± 0.03%) and equilibrium swelling (1.85 ± 0.01% to 6.68 ± 0.03%; 10.12 ± 0.02% to 27.89 ± 0.03%) of formulations was observed at pH 1.2, whereas the higher dynamic (4.33 ± 0.04% to 10.21 ± 0.01%) and equilibrium swelling (22.25 ± 0.03% to 55.48 ± 0.04%) was recorded at pH 7.4. These findings clearly indicated that the synthesized 5-FULH have potential swelling characteristics in pH 6.8 that will enhance the drug's release in the same pH medium. The porosity values of formulated 5-FULH range from 34% to 62% with different weight ratios of AM, AA, and GA. The gel fractions data showed variations ranging from 74 ± 0.4% (A1) to 94 ± 0.2% (B3). However, formulation A1 reported the highest 24 ± 0.1% and B3 the lowest 09 ± 0.3% sol fractions rate among the formulations. Around 20% drug release from the 5-FULH was found at 1 h in an acidic media (pH1.2), whereas >65% of drug release (pH7.4) was observed at around 25 h. These findings concluded that GA crosslinked 5-FU loaded AM and AA based hydrogels would be a potential pH-sensitive oral controlled colon drug delivery carrier.
13 citations
TL;DR: In this article, the authors developed chondroitin sulfate/carbopol-co-poly(acrylic acid) (CS/CBP-Co-PAA) hydrogels for controlled delivery of diclofenac sodium (DS).
Abstract: The purpose of the current investigation was to develop chondroitin sulfate/carbopol-co-poly(acrylic acid) (CS/CBP-co-PAA) hydrogels for controlled delivery of diclofenac sodium (DS). Different concentrations of polymers chondroitin sulfate (CS), carbopol 934 (CBP), and monomer acrylic acid (AA) were cross-linked by ethylene glycol dimethylacrylate (EGDMA) in the presence of ammonium peroxodisulfate (APS) (initiator). The fabricated hydrogels were characterized for further experiments. Characterizations such as Scanning electron microscopy (SEM), Thermogravimetric analysis (TGA), Differential scanning calorimetry (DSC), Powder X-ray diffractometry (PXRD), and Fourier transform infrared spectroscopy (FTIR) were conducted to understand the surface morphology, thermodynamic stability, crystallinity of the drug, ingredients, and developed hydrogels. The swelling and drug release studies were conducted at two different pH mediums (pH 1.2 and 7.4), and pH-dependent swelling and drug release was shown due to the presence of functional groups of both polymers and monomers; hence, greater swelling and drug release was observed at the higher pH (pH 7.4). The percent drug release of the developed system and commercially available product cataflam was compared and high controlled release of the drug from the developed system was observed at both low and high pH. The mechanism of drug release from the hydrogels followed Korsmeyer–Peppas model. Conclusively, the current research work demonstrated that the prepared hydrogel could be considered as a suitable candidate for controlled delivery of diclofenac sodium.
12 citations
TL;DR: In this paper, pH-responsive carbopol 934/sodium polystyrene sulfonate-co-poly(acrylic acid) (CP/SpScPAA) hydrogels were developed by the free radical polymerization technique for the controlled release of Ketorolac tromethamine.
Abstract: Ketorolac tromethamine is a non-steroidal anti-inflammatory drug used in the management of severe pain. The half-life of Ketorolac tromethamine is within the range of 2.5–4 h. Hence, repeated doses of Ketorolac tromethamine are needed in a day to maintain the therapeutic level. However, taking several doses of Ketorolac tromethamine in a day generates certain complications, such as acute renal failure and gastrointestinal ulceration. Therefore, a polymeric-controlled drug delivery system is needed that could prolong the release of Ketorolac tromethamine. Therefore, in the current study, pH-responsive carbopol 934/sodium polystyrene sulfonate-co-poly(acrylic acid) (CP/SpScPAA) hydrogels were developed by the free radical polymerization technique for the controlled release of Ketorolac tromethamine. Monomer acrylic acid was crosslinked with the polymers carbopol 934 and sodium polystyrene sulfonate by the cross-linker N’,N’-methylene bisacrylamide. Various studies were conducted to evaluate and assess the various parameters of the fabricated hydrogels. The compatibility of the constituents used in the preparation of hydrogels was confirmed by FTIR analysis, whereas the thermal stability of the unreacted polymers and developed hydrogels was analyzed by TGA and DSC, respectively. A smooth and porous surface was indicated by SEM. The crystallinity of carbopol 934, sodium polystyrene sulfonate, and the prepared hydrogels was evaluated by PXRD, which revealed a reduction in the crystallinity of reactants for the developed hydrogels. The pH sensitivity of the polymeric hydrogel networks was confirmed by dynamic swelling and in vitro release studies with two different pH media i.e., pH 1.2 and 7.4, respectively. Maximum swelling was exhibited at pH 7.4 compared to pH 1.2 and, likewise, a greater percent drug release was perceived at pH 7.4. Conclusively, we can demonstrate that the developed pH-sensitive hydrogel network could be employed as a suitable carrier for the controlled delivery of Ketorolac tromethamine.
8 citations
TL;DR: In this article , a reduced graphene oxide (RGO) nanocomposite decorated with silver nanoparticles (AgNPs) was used for the degradation of organic contaminants, which is a promising strategy for controlling environmental damage and treating wastewater.
Abstract: The breakdown of organic contaminants is a promising strategy for controlling environmental damage and treating wastewater. Even though several heterogeneous catalysts have been developed with the intention of achieving this objective, the issue of effective degradation of organic pollutants remains difficult. In this paper, we provide a simple and environmentally friendly method for making a reduced graphene oxide (RGO) nanocomposite decorated with silver nanoparticles (AgNPs). Various spectroscopic techniques were used to thoroughly characterize the nanocomposite, which was found to be composed of monodispersed AgNPs with a diameter of approximately 2–11 nm that were uniformly distributed over the surface of RGO. To ensure the versatility of the catalyst, both cationic and anionic dyes and a model 4-nitrophenol (4-NP) reduction have been tested. It has been hypothesized that the AgNPs cause oxidative breakdown of organic contaminants by facilitating electronic transitions that lead to conductive RGO nanosheets in a way that is physically possible.
6 citations
TL;DR: In this paper , the authors used free radical polymerization (FRP) to synthesize a new polymeric network of hydrogels for the controlled drug delivery system, which can be used for a long period of time.
4 citations
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TL;DR: The newest developments in chitosan hydrogel preparation are investigated and the design parameters in the development of physically and chemically cross-linked hydrogels are defined.
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TL;DR: In this paper, a coupled diffusion/relaxation model is presented for general analysis of the release behavior of controlled release systems using a coupled diffusional and relaxation model, and the general form of this equation's exponent is related to the geometric shape of the releasing device through its aspect ratio.
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