Journal ArticleDOI
Preparation of biodegradable microspheres and microcapsules: 2. Polyactides and related polyesters
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TLDR
A general survey of the manufacturing methods of microspheres and microcapsules based on biodegradable polyesters, including polylactides, polyglycolide, polyhydroxybutyrate, polycaprolactone, polycarbonates and related copolymers is presented in this paper.About:
This article is published in Journal of Controlled Release.The article was published on 1991-09-01. It has received 282 citations till now. The article focuses on the topics: Polycaprolactone & Polyglycolide.read more
Citations
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Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier
TL;DR: This manuscript describes the various fabrication techniques for these devices and the factors affecting their degradation and drug release.
Journal ArticleDOI
Biodegradable polymeric nanoparticles as drug delivery devices
TL;DR: This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.
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The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices.
TL;DR: This review discusses the various traditional and novel techniques (such as in situ microencapsulation) of preparing various drug loaded PLGA devices, with emphasis on preparing microparticles.
Journal ArticleDOI
Properties of lactic acid based polymers and their correlation with composition
Anders Södergård,Mikael Stolt +1 more
TL;DR: In this paper, the properties of lactic acid based polymers and the correlation to the structure of the polymers are discussed, including the thermophysical properties, the solubility, the miscibility, and the mechanical properties.
Patent
Anti-angiogenic compositions and methods of use
TL;DR: In this article, an anti-angiogenic factor and a polymeric carrier were used for embolization of blood vessels and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.
References
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Journal ArticleDOI
Biodegradable polymers for use in surgery—polyglycolic/poly(actic acid) homo- and copolymers: 1
D.K. Gilding,A.M. Reed +1 more
TL;DR: In this paper, the historical development of polyglycolic acid (PGA) and polylactic acid (PLA) polymers and copolymers for use in surgery is set down.
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Degradation rates of oral resorbable implants (polylactates and polyglycolates): Rate modification with changes in PLA/PGA copolymer ratios
TL;DR: Control of degradation rate of the implant could best be attained by varying the composition of PLA and PGA between 75% and 100% PLA along with a corresponding 25% to 0% PGA.
Journal ArticleDOI
Biodegradable poly(lactic acid) polymers
TL;DR: A biological in vitro method for determining the degradation of poly(lactic acids) indicates, in accordance with expectations, that poly(dl-lactic acid) degrades at a faster rate than L(+) lactic acid.
Journal ArticleDOI
Applications of PHB - a microbially produced biodegradable thermoplastic
TL;DR: ICI has recently made available a new range of environmentally degradable thermoplastics made by bacteria from renewable substrates, which are now being evaluated in speciality applications as discussed by the authors.
Journal ArticleDOI
Aliphatic polyesters. I. The degradation of poly(ϵ‐caprolactone) in vivo
TL;DR: The degradation of poly(ϵ-caprolactone) in rabbits, rats, and water was studied by measurement of changes in intrinsic viscosity, molecular weight, crystallinity, Young's modulus, and weight.