Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease.
Adeera Levin,George L. Bakris,Mark E. Molitch,Maartje Smulders,J. Tian,L. A. Williams,Dennis L. Andress +6 more
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Multivariate analysis revealed that DM, increased urinary albumin/creatinine ratio and lower eGFR predicted lower values of 1,25 OH2 D3, but not 25(OH)D3 levels, were seen across deciles of eG FR (P<0.001).About:
This article is published in Kidney International.The article was published on 2007-01-01 and is currently open access. It has received 1367 citations till now. The article focuses on the topics: Parathyroid hormone & Etelcalcetide.read more
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KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)
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Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease.
Tamara Isakova,Patricia Wahl,Gabriela Vargas,Orlando M. Gutiérrez,Julia J. Scialla,Huiliang Xie,Dina Appleby,Lisa Nessel,Keith Bellovich,Jing Chen,L. Lee Hamm,Crystal A. Gadegbeku,Edward Horwitz,Raymond R. Townsend,Cheryl A.M. Anderson,James P. Lash,Chi-yuan Hsu,Mary B. Leonard,Myles Wolf +18 more
TL;DR: Increased FGF23 is a common manifestation of CKD that develops earlier than increased phosphate or PTH, and may be a sensitive early biomarker of disordered phosphorus metabolism in patients with CKD and normal serum phosphate levels.
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Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate
TL;DR: A major role is suggested for elevated P in promoting osteogenic/chondrogenic differentiation of VSMC, whereas elevated Ca has a predominant role in promoting VSMC apoptosis and vesicle release.
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KDOQI Clinical Practice Guideline for Nutrition in CKD: 2020 Update
T. Alp Ikizler,Jerrilynn D. Burrowes,Laura Byham-Gray,Katrina L. Campbell,Juan Jesus Carrero,Winnie Chan,Denis Fouque,Allon N. Friedman,Sana Ghaddar,D. Jordi Goldstein-Fuchs,George A. Kaysen,Joel D. Kopple,Daniel Teta,Angela Yee-Moon Wang,Lilian Cuppari +14 more
TL;DR: The 2020 update to the KDOQI Clinical Practice Guideline for Nutrition in CKD provides comprehensive up-to-date information on the understanding and care of patients with chronic kidney disease (CKD), especially in terms of their metabolic and nutritional milieu for the practicing clinician and allied health care workers.
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Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial
Dick de Zeeuw,Rajiv Agarwal,Michael Amdahl,Paul Audhya,Daniel W. Coyne,Tushar S. Garimella,Hans-Henrik Parving,Yili Pritchett,Giuseppe Remuzzi,Eberhard Ritz,Dennis L. Andress +10 more
TL;DR: Addition of 2 μg/day paricalcitol to RAAS inhibition safely lowers residual albuminuria in patients with diabetic nephropathy, and could be a novel approach to lower residual renal risk in diabetes.
References
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Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
TL;DR: The longitudinal glomerular filtration rate was estimated among 1,120,295 adults within a large, integrated system of health care delivery in whom serum creatinine had been measured between 1996 and 2000 and who had not undergone dialysis or kidney transplantation.
Journal ArticleDOI
Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
TL;DR: In this paper, the longitudinal glomerular filtration rate (GFR) among 1,120,295 adults within a large, integrated system of health care delivery in whom serum creatinine had been measured between 1996 and 2000 and who had not undergone dialysis or kidney transplantation.
Journal Article
K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease
Shaul G. Massry,Jack W. Coburn,Glenn M. Chertow,Keith A. Hruska,Craig B. Langman,Hartmut H. Malluche,Kevin J. Martin,Linda McCann,James T. McCarthy,Sharon M. Moe,Isidro B. Salusky,Donald J. Sherrand,Miroslaw Smogorzewski,Kline Bolton,Charles Turkelson,Karyn A. Tappe,Stephen Tregear,James Reston,Wendy Bruening,Mark Monteforte,Janice Kaczmarek,Vivian Coates,George R. Bailie,Bryan N. Becker,Gavin J. Becker,Jerrilynn D. Burrowes,Fernando Carrera,David N. Churchill,Allan J. Collins,Peter W. Crooks,Dick DeZeeuw,Thomas A. Golper,Frank A. Gotch,Antonio M. Gotto,Roger Greenwood,Joel W. Greer,Richard H. Grimm,William E. Haley,Ronald J. Hogg,Alan R. Hull,Lawrence G. Hunsicker,Cynda Ann Johnson,Michael J. Klag,Saulo Klahr,Norbert Lameire,Francesco Locatelli,Sally McCulloch,Maureen Michael,Joseph V. Nally,John M. Newmann,Allen R. Nissenson,Keith C. Norris,Gregorio T. Obrador,William F. Owen,Thakor G. Patel,Glenda Payne,Claudio Ronco,Rosa A. Rivera-Mizzoni,Anton C. Schoolwerth,Robert A. Star,Michael W. Steffes,Theodore I. Steinman,John Pierre Wauters,Nanette K. Wenger,Josephine P. Briggs,Thomas H. Hostetter,Garabed Eknoyan,Aderra Levin,Nathan W. Levin,Sharon Andreoli,Sally Burrows-Hudson,Derrick Latos,Donna Mapes,Edith Oberley,Brian J.G. Pereira,Nadine Ferguson,Donna Fingerhut,Anthony Gucciardo,Margaret Klette,Doreen Mallard,Kerry Willis +80 more
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Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis
Geoffrey A. Block,Preston S. Klassen,J. Michael Lazarus,Norma J. Ofsthun,Edmund G. Lowrie,Glenn M. Chertow +5 more
TL;DR: Hyperphosphatemia and hyperparathyroidism were significantly associated with all-cause, cardiovascular, and fracture-related hospitalization, and the population attributable risk percentage for disorders of mineral metabolism was 17.5%, owing largely to the high prevalence of hyperph phosphatemia.
Journal ArticleDOI
Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: A national study
TL;DR: This study concludes that a large percentage of hemodialysis patients who have a serum phosphorus level above 6.5 mg/dL and that this places them at increased risk of death, and supports the need for vigorous control of hyperphosphatemia to improve patient survival.
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