Prevalence of Symptoms of Bladder Pain Syndrome/Interstitial Cystitis Among Adult Females in the United States
TL;DR: It is suggested that bladder pain syndrome/interstitial cystitis symptoms are widespread among United States women and associated with considerable disability, and underdiagnosed, and this first population based symptom prevalence estimate is provided.
About: This article is published in The Journal of Urology.The article was published on 2011-08-01 and is currently open access. It has received 459 citations till now. The article focuses on the topics: Interstitial cystitis & Population.
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TL;DR: This amendment is to provide an updated clinical framework for the diagnosis and treatment of interstitial cystitis/bladder pain syndrome based upon data received since the publication of original guideline in 2011.
513 citations
Cites background from "Prevalence of Symptoms of Bladder P..."
...S.(5) This study yielded prevalence estimates from 2....
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TL;DR: The past and current techniques available for fabricating and remotely controlling drug delivery systems are reviewed and the application of new technologies (e.g. 3D printing) in this field are addressed.
202 citations
TL;DR: In this article, the authors developed validated case definitions to identify interstitial cystitis/bladder pain syndrome in women and chronic prostatitis/chronic pelvic pain disorder in men.
190 citations
01 Jan 2013
TL;DR: The prevalence of interstitial cystitis/bladder pain syndrome symptoms in men approaches that in women, suggesting that this condition may be underdiagnosed in the male population.
Abstract: PURPOSE
As part of the RICE (RAND Interstitial Cystitis Epidemiology) study, we developed validated case definitions to identify interstitial cystitis/bladder pain syndrome in women and chronic prostatitis/chronic pelvic pain syndrome in men. Using population based screening methods, we applied these case definitions to determine the prevalence of these conditions in men.
MATERIALS AND METHODS
A total of 6,072 households were contacted by telephone to screen for men who had symptoms of interstitial cystitis/bladder pain syndrome or chronic prostatitis/chronic pelvic pain syndrome. An initial 296 men screened positive, of whom 149 met the inclusionary criteria and completed the telephone interview. For interstitial cystitis/bladder pain syndrome 2 case definitions were applied (1 with high sensitivity and 1 with high specificity), while for chronic prostatitis/chronic pelvic pain syndrome a single case definition (with high sensitivity and specificity) was used. These case definitions were used to classify subjects into groups based on diagnosis.
RESULTS
The interstitial cystitis/bladder pain syndrome weighted prevalence estimates for the high sensitivity and high specificity definitions were 4.2% (3.1-5.3) and 1.9% (1.1-2.7), respectively. The chronic prostatitis/chronic pelvic pain syndrome weighted prevalence estimate was 1.8% (0.9-2.7). These values equate to 1,986,972 (95% CI 966,042-2,996,924) men with chronic prostatitis/chronic pelvic pain syndrome and 2,107,727 (95% CI 1,240,485-2,974,969) men with the high specificity definition of interstitial cystitis/bladder pain syndrome in the United States. The overlap between men who met the high specificity interstitial cystitis/bladder pain syndrome case definition or the chronic prostatitis/chronic pelvic pain syndrome case definition was 17%.
CONCLUSIONS
Symptoms of interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome are widespread among men in the United States. The prevalence of interstitial cystitis/bladder pain syndrome symptoms in men approaches that in women, suggesting that this condition may be underdiagnosed in the male population.
174 citations
TL;DR: It could be suggested to classify the patients with emphasis on the phenotype, as well as their symptom clusters, to tailor the diagnostic and management choices according to the observed biomarkers of IC/PBS.
Abstract: Interstitial cystitis/painful bladder syndrome (IC/PBS) is a chronic pain syndrome and a chronic inflammatory condition prevalent in women that leads to urgency, sleep disruption, nocturia and pain in the pelvic area, to the detriment of the sufferer’s quality of life. The aim of this review is to highlight the newest diagnostic strategies and potential therapeutic techniques. A comprehensive literature review was performed on MEDLINE, PubMed, and Cochrane databases gathering all literature about “Interstitial cystitis” and “Painful Bladder Syndrome”. Visual analogue scales, epidemiological strategies, pain questionnaires and similar techniques were not included in this literature survey. The etiology, exact diagnosis and epidemiology of IC/PBS are still not clearly understood. To date, its prevalence is estimated to be in the range of 45 per 100,000 women and 8 per 100,000 men, whereas joint prevalence in both sexes is 10.6 cases per 100,000. There are no “gold standards” in the diagnosis or detection of IC/PBS, therefore, several etiological theories were investigated, such as permeability, glycosaminoglycans, mast cell, infection and neuroendocrine theory to find new diagnostic strategies and potential biomarkers. Due to the fact that this disease is of an intricate nature, and that many of its symptoms overlap with other concomitant diseases, it could be suggested to classify the patients with emphasis on the phenotype, as well as their symptom clusters, to tailor the diagnostic and management choices according to the observed biomarkers.
149 citations
Cites background from "Prevalence of Symptoms of Bladder P..."
...Approximately 8 million women may be suffering from IC/PBS and many more may still be undiagnosed [74, 88]....
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References
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TL;DR: The authors showed that nonresponse bias can be translated into causal models to guide hypotheses about when nonresponse causes bias, but the linkage between nonresponse rates and nonresponse biases is absent.
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2,290 citations
TL;DR: In this paper, the authors investigate the relationship between nonresponse rates and nonresponse bias in statistics of interest, using a variety of designs: sampling frames with rich variables, data from administrative records matched to sample case, use of screening- interview data to describe nonrespondents to main interviews, followup of non respondents to initial phases of field effort, and measures of be- havior intentions to respond to a survey.
Abstract: Fifty-nine methodological studies were designed to esti- mate the magnitude of nonresponse bias in statistics of interest. These studies use a variety of designs: sampling frames with rich variables, data from administrative records matched to sample case, use of screening- interview data to describe nonrespondents to main interviews, followup of nonrespondents to initial phases of field effort, and measures of be- havior intentions to respond to a survey. This permits exploration of which circumstances produce a relationship between nonresponse rates and nonresponse bias and which, do not. The predictors are design fea- tures of the surveys, characteristics of the sample, and attributes of the survey statistics computed in the surveys.
1,193 citations
TL;DR: Both indices should be useful in the evaluation and management of patients with IC and should be particularly useful in clinical trials of new therapies for this condition, where reliable, validated, and reproducible outcome measures are critically important.
621 citations
TL;DR: The prevalence of interstitial cystitis in the United States is more than 50% greater than previously reported and 3-fold greater than that reported in Europe.
290 citations
TL;DR: The prevalence and incidence of interstitial cystitis is significantly higher for women and men than previously published estimates and men account for a higher proportion of patients with IC than has previously been recognized.
192 citations