Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial
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...Anglo-Scandinavian Cardiac Outcomes Trial—Lipid-Lowering Arm In contrast to the ALLHAT lipid-lowering component, a markedly different result was obtained in hypertensive patients in ASCOT-LLA (7)....
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...These include the Heart Protection Study (HPS),4 the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER),5 Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial—Lipid-Lowering Trial (ALLHAT-LLT),6 Anglo-Scandinavian Cardiac Outcomes Trial—Lipid-Lowering Arm (ASCOT-LLA),7 and the Pravastatin or Atorvastatin Evaluation and Infection—Thrombolysis in Myocardial Infarction 22 (PROVE IT–TIMI 22) trial.8 These trials addressed issues that had not been adequately addressed in previous statin trials....
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...These include the Heart Protection Study (HPS) (4), the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) (5), Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial—Lipid-Lowering Trial (ALLHAT-LLT) (6), Anglo-Scandinavian Cardiac Outcomes Trial—Lipid-Lowering Arm (ASCOT-LLA) (7), and the Pravastatin or Atorvastatin Evaluation and Infection— Thrombolysis in Myocardial Infarction 22 (PROVE IT–TIMI 22) trial (8)....
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...In contrast to the ALLHAT lipid-lowering component, a markedly different result was obtained in hypertensive patients in ASCOT-LLA.7 In this study, 19 342 hypertensive patients, 40 to 79 years old and having at least 3 other cardiovascular risk factors, were randomized to 1 of 2 antihypertensive regimens....
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...(4,5,7,8) demonstrate that effective LDL-C reduction sub-...
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