Journal ArticleDOI
Primary intracranial angiomatoid fibrous histiocytoma presenting with anaemia and migraine-like headaches and aura as early clinical features.
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TLDR
A 17-year-old female with migraine with aura complained of fatigue and was diagnosed with anemia, and brain MRI showed a bi-lobed extra-axial intracerebral tumor encroaching both parieto-occipital regions, leading to the first report of an intracranial AFH presenting as migraine with visual aura and anemia.Abstract:
A 17-year-old female with migraine with aura complained of fatigue and was diagnosed with anemia. Three years later, changes in her headache pattern prompted hospital referral. Brain MRI showed a bi-lobed extra-axial intracerebral tumor encroaching both parieto-occipital regions. The resection specimen yielded a rare diagnosis of primary intracranial angiomatoid fibrous histiocytoma (AFH). Tumor removal resulted in cessation of her migraine and anemia. AFH may cause systemic symptoms – in this case fatigue and anemia – long before focal neurological symptoms are present. This is the first report of an intracranial AFH presenting as migraine with visual aura and anemia.read more
Citations
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Intracranial myxoid mesenchymal tumors with EWSR1-CREB family gene fusions: myxoid variant of angiomatoid fibrous histiocytoma or novel entity?
Tejus A. Bale,Angelica Oviedo,Harry P.W. Kozakewich,Caterina Giannini,Phani K. Davineni,Keith L. Ligon,Keith L. Ligon,Sanda Alexandrescu +7 more
TL;DR: Three pediatric patients with intracranial EWSR1‐rearranged myxoid mesenchymal neoplasm are presented and copy number and mutational changes presented here provide support for future studies to further clarify this issue.
Journal ArticleDOI
Intracranial Angiomatoid Fibrous Histiocytoma with EWSR1-CREB Family Fusions: A Report of 2 Pediatric Cases.
Athanasios Konstantinidis,Edmund Cheesman,James O'Sullivan,Juljia Pavaine,Shivaram Avula,Barry Pizer,John-Paul Kilday +6 more
TL;DR: The results suggest that a tumor spectrum incorporating classical and myxoid intracranial AFHs can occur in children and that gross total resection represents the treatment strategy of choice at diagnosis or following recurrence.
Journal ArticleDOI
Intracranial Angiomatoid Fibrous Histiocytoma: Case Report and Literature Review
Mohammed Alshareef,Zayed Almadidy,Tiffany G. Baker,Arie Perry,Cynthia T. Welsh,William A. Vandergrift +5 more
TL;DR: A rare case of an older patient with a large, petrous apex AFH that was clinically mistaken for a trigeminal nerve schwannoma is presented, and gross total resection of this lesion is preferable.
Journal ArticleDOI
Intracranial Myxoid Mesenchymal Tumor with EWSR1-ATF1 Fusion
Leomar Y. Ballester,Leomar Y. Ballester,Jeanne M. Meis,Alexander J. Lazar,Sujit S. Prabhu,Kimberly B Hoang,Norman E. Leeds,Gregory N. Fuller +7 more
TL;DR: A case of intracranial myxoid mesenchymal tumor with an EWSR1-ATF1 fusion in an adult patient is reported, and the existing literature on this recently described entity is reviewed.
Journal ArticleDOI
Intracranial Myxoid Variant of Angiomatoid Fibrous Histiocytoma: A Case Report and Literature Review
TL;DR: A 58-year-old woman presenting with the first episode of generalized seizure due to an extra-axial lesion with homogenous contrast enhancement in the right parietal lobe is illustrated the need to consider the myxoid variant of intracranial AFH in the differential diagnosis of meningioma-like tumors.
References
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Journal ArticleDOI
Angiomatoid malignant fibrous histiocytoma. A distinct fibrohistiocytic tumor of children and young adults simulating a vascular neoplasm
TL;DR: Most likely it is a tumor of fibroblast‐ and histiocyte‐like cells, akin to malignant fibrous histiocytoma, but different in its age incidence, microscopic appearance, and behavior.
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Primary intracerebral angiomatoid fibrous histiocytoma: report of a case with a t(12;22)(q13;q12) causing type 1 fusion of the EWS and ATF-1 genes.
TL;DR: The first pathologically confirmed case of an AFH presenting as an intracerebral primary in a previously healthy 25-year-old man is reported, and genetic analyses revealed a t(12;22)(q13;q12) and a unique underlying clear cell sarcomalike type 1 EWS/ATF-1 gene fusion.
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Utility of FISH in the diagnosis of angiomatoid fibrous histiocytoma: a series of 18 cases
Munir R. Tanas,Brian P. Rubin,Elizabeth A. Montgomery,Sondra L. Turner,James R. Cook,Raymond R. Tubbs,Steven D. Billings,John R. Goldblum +7 more
TL;DR: This study affirms that the rearrangement of EWSR1 is a common genetic event in angiomatoid fibrous histiocytoma, and is thus useful diagnostically.
Journal ArticleDOI
Intracranial angiomatoid fibrous histiocytoma presenting as recurrent multifocal intraparenchymal hemorrhage.
Pawel G. Ochalski,James T. Edinger,Michael B. Horowitz,William R. Stetler,Geoffrey Murdoch,Amin B. Kassam,Johnathan A. Engh +6 more
TL;DR: The case of a patient with recurrent hemorrhage due to primary multifocal intracranial AFH, initially misdiagnosed as a cavernous malformation and then an unusual meningioma, was finally correctly identified when there was a large enough intact resection specimen to reveal the characteristic histological pattern.