Journal ArticleDOI
Principles of Population Genetics.
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This article is published in Biometrics.The article was published on 1981-06-01. It has received 5807 citations till now. The article focuses on the topics: Population genetics.read more
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A unified mixed-model method for association mapping that accounts for multiple levels of relatedness
Jianming Yu,Gaël Pressoir,William H. Briggs,Irie Vroh Bi,Masanori Yamasaki,John Doebley,Michael D. McMullen,Michael D. McMullen,Brandon S. Gaut,Dahlia M. Nielsen,James B. Holland,James B. Holland,Stephen Kresovich,Edward S. Buckler,Edward S. Buckler +14 more
TL;DR: A unified mixed-model approach to account for multiple levels of relatedness simultaneously as detected by random genetic markers is developed and provides a powerful complement to currently available methods for association mapping.
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Five years of GWAS discovery
Peter M. Visscher,Peter M. Visscher,Matthew A. Brown,Mark I. McCarthy,Mark I. McCarthy,Jian Yang +5 more
TL;DR: The past five years have seen many scientific and biological discoveries made through the experimental design of genome-wide association studies (GWASs), which were aimed at detecting variants at genomic loci that are associated with complex traits in the population and, in particular, at detecting associations between common single-nucleotide polymorphisms (SNPs) and common diseases such as heart disease, diabetes, auto-immune diseases, and psychiatric disorders.
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Poppr: an R package for genetic analysis of populations with clonal, partially clonal, and/or sexual reproduction.
TL;DR: The R package poppr is developed providing unique tools for analysis of data from admixed, clonal, mixed, and/or sexual populations, and functions for genotypic diversity and clone censoring are specific for clonal populations.
Journal ArticleDOI
Conceptual Synthesis in Community Ecology
TL;DR: Organizing the material of community ecology according to this framework can clarify the essential similarities and differences among the many conceptual and theoretical approaches to the discipline, and allow for the articulation of a very general theory of community dynamics.
Journal ArticleDOI
Linkage disequilibrium in the human genome
David Reich,Michele Cargill,Michele Cargill,Stacey Bolk,James S. Ireland,Pardis C. Sabeti,Daniel J. Richter,Thomas Lavery,Rose Kouyoumjian,Shelli F. Farhadian,Ryk Ward,Eric S. Lander +11 more
TL;DR: The results illuminate human history, suggesting that LD in northern Europeans is shaped by a marked demographic event about 27,000–53,000 years ago, implying that LD mapping is likely to be practical in this population.