Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak.
Tao Zhang,Qunfu Wu,Zhigang Zhang +2 more
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TLDR
Genomic and evolutionary evidence of the occurrence of a SARS-CoV-2-like CoV (named Pangolin-Cov) in dead Malayan pangolins is found and suggests that pangolin species are a natural reservoir of SARSAbout:
This article is published in Current Biology.The article was published on 2020-04-06 and is currently open access. It has received 1213 citations till now. The article focuses on the topics: Pangolin & Disease reservoir.read more
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Characteristics of SARS-CoV-2 and COVID-19
TL;DR: The basic virology of SARS-CoV-2 is described, including genomic characteristics and receptor use, highlighting its key difference from previously known coronaviruses.
Features, Evaluation and Treatment Coronavirus (COVID-19)
TL;DR: The effects of the epidemic caused by the new CoV has yet to emerge as the situation is quickly evolving, and world governments are at work to establish countermeasures to stem possible devastating effects.
Journal ArticleDOI
A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells.
TL;DR: It is reported that the cellular protease furin cleaves the spike protein at the S1/S2 site and that cleavage is essential for S-protein-mediated cell-cell fusion and entry into human lung cells and identifies furin as a potential target for therapeutic intervention.
Journal ArticleDOI
COVID-19 and Cardiovascular Disease.
Kevin J. Clerkin,Justin Fried,Jayant Raikhelkar,Gabriel Sayer,Jan M. Griffin,Amirali Masoumi,Sneha S. Jain,Daniel Burkhoff,Deepa Kumaraiah,Le Roy E. Rabbani,Allan Schwartz,Nir Uriel +11 more
TL;DR: COVID-19 poses a challenge for heart transplantation, affecting donor selection, immunosuppression, and posttransplant management, and there are a number of promising therapies under active investigation to treat and prevent the disease.
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Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir.
Wanchao Yin,Wanchao Yin,Chunyou Mao,Xiaodong Luan,Xiaodong Luan,Dan-Dan Shen,Qingya Shen,Haixia Su,Xiaoxi Wang,Fulai Zhou,Wenfeng Zhao,Minqi Gao,Shenghai Chang,Yuan Chao Xie,Guanghui Tian,He wei Jiang,Sheng-Ce Tao,Jingshan Shen,Yi Jiang,Hualiang Jiang,Yechun Xu,Shuyang Zhang,Yan Zhang,H. Eric Xu +23 more
TL;DR: Cryo–electron microscopy structures of the SARS-CoV-2 RdRp provide insights into the mechanism of viral RNA replication and a rational template for drug design to combat the viral infection.
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