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Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial

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TLDR
In patients with predicted severe acute pancreatitis, probiotic prophylaxis with this combination of probiotic strains did not reduce the risk of infectious complications and was associated with an increased risk of mortality.
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This article is published in The Lancet.The article was published on 2008-02-23. It has received 1058 citations till now. The article focuses on the topics: Placebo-controlled study & Pancreatitis.

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Citations
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Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus

TL;DR: This international, web-based consensus provides clear definitions to classify acute pancreatitis using easily identified clinical and radiologic criteria and should encourage widespread adoption.
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Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.).

TL;DR: These guidelines offer basic recommendations that are supported by review and analysis of the current literature, other national and international guidelines, and a blend of expert opinion and clinical practicality that are directed toward generalized patient populations.
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American College of Gastroenterology guideline: management of acute pancreatitis.

TL;DR: As the diagnosis of AP is most often established by clinical symptoms and laboratory testing, contrast-enhanced computed tomography and/or magnetic resonance imaging of the pancreas should be reserved for patients in whom the diagnosis is unclear or who fail to improve clinically.
References
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Journal ArticleDOI

APACHE II: a severity of disease classification system.

TL;DR: The form and validation results of APACHE II, a severity of disease classification system that uses a point score based upon initial values of 12 routine physiologic measurements, age, and previous health status, are presented.
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Gut flora in health and disease

TL;DR: Gut flora might be an essential factor in certain pathological disorders, including multisystem organ failure, colon cancer, and inflammatory bowel diseases, and Probiotics and prebiotics are known to have a role in prevention or treatment of some diseases.
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A Clinically Based Classification System for Acute Pancreatitis: Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 Through 13, 1992

TL;DR: In the absence of accepted definitions for acute pancreatitis and its complications, it has not been possible to devise a clinical classification system useful for case management as discussed by the authors, which is why a group of 40 international authorities from six medical disciplines and 15 countries participated in a three-day meeting and open discussion.
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Acute pancreatitis: value of CT in establishing prognosis.

TL;DR: A CT severity index, based on a combination of peripancreatic inflammation, phlegmon, and degree of pancreatic necrosis as seen at initial CT study, was developed and showed clear trends in patients who initially had or developed more than 30% necrosis.
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Should Immunonutrition Become Routine in Critically Ill Patients?A Systematic Review of the Evidence

TL;DR: Investigating the relationship between enteral nutrition supplemented with immune-enhancing nutrients and infectious complications and mortality rates in critically ill patients found that studies using commercial formulas with high arginine content were associated with a significant reduction in infectious complication rates and a trend toward a lower mortality rate compared with other immune- enhancing diets.
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