Journal ArticleDOI
Probiotics and the Treatment of Parkinson's Disease: An Update.
Hamed Mirzaei,Saman Sedighi,Ebrahim Kouchaki,Erfaneh Barati,Ehsan Dadgostar,Michael Aschner,Omid Reza Tamtaji,Omid Reza Tamtaji +7 more
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TLDR
In this article, the effects of probiotics on motor and non-motor symptoms as well as various cellular and molecular pathways in Parkinson's disease were summarized, and it was shown that probiotic supplementation mediates these pharmacological effects by targeting a variety of cellular processes, i.e., oxidative stress, inflammatory and anti-inflammatory pathways, and apoptosis.Abstract:
Parkinson's disease (PD) is a progressive neurological disorder characterized by motor and non-motor features. Although some progress has been made in conventional PD treatments, these breakthroughs have yet to show high efficacy in treating this neurodegenerative disease. Probiotics are live microorganisms that confer health benefits on the host when administered in adequate amounts. Probiotics have putative anticancer, antioxidative, anti-inflammatory, and neuroprotective effects. Multiple lines of evidence show that probiotics control and improve several motor and non-motor symptoms in patients and experimental animal models of PD. Probiotic supplementation mediates these pharmacological effects by targeting a variety of cellular and molecular processes, i.e., oxidative stress, inflammatory and anti-inflammatory pathways, as well as apoptosis. Herein, we summarize the effects of probiotics on motor and non-motor symptoms as well as various cellular and molecular pathways in PD.read more
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Journal ArticleDOI
Recent developments in the probiotics as live biotherapeutic products (LBPs) as modulators of gut brain axis related neurological conditions
Duygu Ağagündüz,Feray Gencer-Bingol,Elif Çelik,Özge Cemali,Çiler Özenir,Fatih Özogul,Raffaele Capasso +6 more
TL;DR: In this article , the authors discuss the role of probiotics in the pathogenesis of diseases that age day by day in the modern world via the gut-brain axis, and discuss the novel roles of LBPs in some gut brain axis related conditions in light of recent studies.
Journal ArticleDOI
Gut Microbiota: A Novel Therapeutic Target for Parkinson’s Disease
TL;DR: This review summarizes the recent studies in PD-associated gut microbiota profiles and functions, the potential roles, and mechanisms of gut microbiota in PD, and gut microbiota-targeted interventions for PD.
Journal ArticleDOI
The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment
Angelica Varesi,Lucrezia Irene Maria Campagnoli,Foroogh Fahmideh,E Pierella,Marcello Romeo,Giovanni Ricevuti,Marchesi Nicoletta,Salvatore Chirumbolo,Alessia Pascale +8 more
TL;DR: Evidence for GM alterations and leaky gut in PD patients is presented, the potential of GM-based signatures to serve as disease biomarkers are reviewed, and the emerging role of probiotics, prebiotics, antibiotics, dietary interventions, and fecal microbiota transplantation as supportive therapeutic approaches in PD are highlighted.
Journal ArticleDOI
Probiotics: present and future
TL;DR: This review is devoted to current data on the role of probiotics in the prevention and adjuvant therapy of somatic diseases.
Journal ArticleDOI
The Impact of Nutrition, Physical Activity, Beneficial Microbes, and Fecal Microbiota Transplant for Improving Health
TL;DR: In this article , a pilot clinical trial design is presented to examine the effects of probiotics and exercise in patients with phenylketonuria (PKU), which is the most common inborn error of amino acid metabolism, and it is a complication requiring lifelong dietary intervention.
References
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Journal ArticleDOI
Parkinson’s disease: clinical features and diagnosis
TL;DR: A thorough understanding of the broad spectrum of clinical manifestations of PD is essential to the proper diagnosis of the disease and genetic mutations or variants, neuroimaging abnormalities and other tests are potential biomarkers that may improve diagnosis and allow the identification of persons at risk.
Journal ArticleDOI
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
TL;DR: Overactivated microglia can be detected using imaging techniques and therefore this knowledge offers an opportunity not only for early diagnosis but, importantly, for the development of targeted anti-inflammatory therapies that might slow or halt the progression of neurodegenerative disease.
Journal ArticleDOI
Gut microbiota are related to Parkinson's disease and clinical phenotype.
Filip Scheperjans,Velma T. E. Aho,Pedro A. B. Pereira,Kaisa Koskinen,Lars Paulin,Eero Pekkonen,Elena Haapaniemi,Seppo Kaakkola,Johanna Eerola-Rautio,Marjatta Pohja,Esko Kinnunen,Kari Murros,Petri Auvinen +12 more
TL;DR: The findings suggest that the intestinal microbiome is altered in PD and is related to motor phenotype, and the suitability of the microbiome as a biomarker is warranted.
Journal ArticleDOI
The Role of Oxidative Stress in Neurodegenerative Diseases
TL;DR: The role of oxidative stress in the pathophysiology of neurodegenerative diseases and in vivo measurement of an index of damage by oxidative stress are discussed and future directions will be outlined.
Journal ArticleDOI
Microbiota and neurodevelopmental windows: implications for brain disorders
Yuliya E. Borre,Gerard W. O'Keeffe,Gerard Clarke,Catherine Stanton,Timothy G. Dinan,John F. Cryan +5 more
TL;DR: The concept of parallel and interacting microbial-neural critical windows opens new avenues for developing novel microbiota-modulating based therapeutic interventions in early life to combat neurodevelopmental deficits and brain disorders.
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