Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.
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Cites background from "Production of transforming growth f..."
...This repression was presumably elaborated by the ability of TGF-β to inhibit the expression and function of interleukin 2 (IL-2) and IL-2 receptor...
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"Production of transforming growth f..." refers background or methods in this paper
...TGF-/3 has been purified and partially sequenced, and its gene has been cloned (3-7)....
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...As previously reported (7), the TGF-13 probe recognized an mRNA of ~2....
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...Previous experiments (7) showed the induction of TGF-/3 mRNA...
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...The size-fractionated RNA was probed using a 3~P-labelled Eco R1 insert from ~,/3C1 under high stringency conditions (7)....
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...Using Northern blots, human TGF-/3 mRNA has been identified in a variety of cell types including mitogen-activated nonadherent PBMC (7)....
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"Production of transforming growth f..." refers background in this paper
...Subsequently, TGF-/3 has been shown to have both growth-enhancing and growth-inhibitory properties, and the effect that predominates is dependent upon the particular cell type and the other growth factors present (12, 13)....
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...The bioassay for TGF-/3 depends upon the ability of TGF-t3 to induce anchorage-independent growth of normal rat kidney (NRK) fibroblasts grown in the presence of 5 ng/ml EGF in soft agar....
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...For example, TGF-/3 synergized with plateletderived growth factor to stimulate colony formation by a 3T3 cell line that had been transfected with c-myc, but inhibited colony formation by the same cell stimulated with EGF (12)....
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...This assay relies upon the ability of TGF-/3 to enhance the growth of NRK cells in agar in the presence of EGF (10)....
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"Production of transforming growth f..." refers background in this paper
...This interaction results in the expression of IL-2-R, and the synthesis and secretion of IL-2 (28, 29)....
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