Prognostic and Immunological Role of Key Genes of Ferroptosis in Pan-Cancer.
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TLDR
In this paper, the expression patterns and prognostic roles of SLC7A11, GPX4, and AIFM2 and the relationships between the expression levels of these genes and immune infiltration levels in pan-cancer were analyzed by using TIMER, gene expression profiling interactive analysis (GEPIA), Oncomine, and Kaplan-Meier databases.Abstract:
Solute carrier family 7 member 11 (SLC7A11), glutathione peroxidase 4 (GPX4), and apoptosis inducing factor mitochondria associated 2 (AIFM2) are the key regulators in ferroptosis. However, the expression patterns and prognostic roles of these genes in pan-cancer are still largely unclear. The expression patterns and prognostic roles of SLC7A11, GPX4, and AIFM2 and the relationships between the expression levels of these genes and immune infiltration levels in pan-cancer were analyzed by using TIMER, gene expression profiling interactive analysis (GEPIA), Oncomine, and Kaplan-Meier databases. Our results showed that both SLC7A11 and GPX4 were overexpressed in colorectal cancer, and SLC7A11 was overexpressed in lung cancer. High levels of SLC7A11 and AIFM2 were significantly linked with the shortened disease-free survival and overall survival (OS) in adrenocortical carcinoma (ACC), respectively. And high expression of SLC7A11, GPX4, and AIFM2 were significantly correlated with the shortened OS of acute myeloid leukemia patients. In esophageal carcinoma (ESCA), GPX4 expression was significantly associated with the infiltration of macrophage and myeloid dendritic cell, and AIFM2 expression was significantly associated with the infiltration of CD4+ T cell. Importantly, GPX4 expression was positively correlated with the expression levels of monocyte markers (CD14 and CD115) and M2 macrophage markers (VSIG4 and MS4A4A) both in ESCA and in head and neck squamous cell carcinoma (HNSC). In summary, SLC7A11, GPX4, and AIFM2 are dysregulated in many types of cancers, and are candidate prognostic biomarkers for many types of cancers, and can be used to evaluate the infiltration of immune cells in tumor tissues.read more
Citations
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The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer
TL;DR: The molecular functions of SLC7A11 in normal versus diseased tissues, with a special focus on how it regulates gastrointestinal cancers are discussed, and current therapeutic strategies targeting SLC 7A11 are summarized.
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Ferroptosis Involvement in Glioblastoma Treatment
Andrei Otto Mitre,Alexandru Ioan Florian,Andrei Buruiana,Armand Boer,Ioana Maria Moldovan,Olga Soritau,Stefan Ioan Florian,Sergiu Susman +7 more
TL;DR: An overview of the current knowledge regarding ferroptosis modulation in GBM is provided and agents that target different molecules involved in ferroPTosis and that stimulate this process have been described as potentially adjuvant anti-cancer treatment options.
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IFNγ enhances ferroptosis by increasing JAK-STAT pathway activation to suppress SLCA711 expression in adrenocortical carcinoma
TL;DR: Experimental evidence is provided on the activity and mechanism of ferroptosis enhanced by IFNγ in ACC and may give critical insight into the immunotherapeutic management of ACC.
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Ferroptosis: A New Strategy for Cancer Therapy
TL;DR: This article reviews the research progress of iron death in tumors, and provides a theoretical reference for its further research and clinical application.
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The role of ferroptosis in esophageal cancer
TL;DR: In this article , the authors summarize the core mechanism of ferroptosis in esophageal cancer, the regulation of the signaling pathway and its current application, and emphasize the potential and prospect of using the potential of FerroPTosis in the treatment of esophages cancer.
References
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TL;DR: GEPIA (Gene Expression Profiling Interactive Analysis) fills in the gap between cancer genomics big data and the delivery of integrated information to end users, thus helping unleash the value of the current data resources.
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TL;DR: Targeted metabolomic profiling and chemoproteomics revealed that GPX4 is an essential regulator of ferroptotic cancer cell death and sensitivity profiling in 177 cancer cell lines revealed that diffuse large B cell lymphomas and renal cell carcinomas are particularly susceptible to GPx4-regulated ferroPTosis.
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TL;DR: Tumor Immune Estimation Resource (TIMER) is presented to comprehensively investigate molecular characterization of tumor-immune interactions and provides a user-friendly web interface for dynamic analysis and visualization of these associations, which will be of broad utilities to cancer researchers.
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TL;DR: Oncomine, a bioinformatics initiative aimed at collecting, standardizing, analyzing, and delivering cancer transcriptome data to the biomedical research community, provides an update on the initiative, describes the database and analysis modules, and highlight several notable observations.