Prognostic parameters of in-hospital mortality in COVID-19 patients-An Italian experience.
Massimiliano Ruscica,Chiara Macchi,Simona Iodice,Gregorio Tersalvi,Irene Rota,Simone Ghidini,Leonardo Terranova,Luca Valenti,Luca Valenti,Francesco Amati,Stefano Aliberti,Stefano Aliberti,Alberto Corsini,Francesco Blasi,Francesco Blasi,Stefano Carugo,Stefano Carugo,Valentina Bollati,Marco Vicenzi,Marco Vicenzi +19 more
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TLDR
In this paper, the authors used multivariate Cox regression analysis to test a large spectrum of variables ranging from clinical evaluation to laboratory biomarkers to identify which parameter would best predict all-cause in-hospital mortality in COVID-19 patients.Abstract:
Background During COVID-19 outbreak, Italy was the first country in Europe to be heavily affected with an intensive care unit mortality of 26%. In order to reduce this percentage, physicians should establish clear and objective criteria to stratify COVID-19 patients at high risk of in-hospital death. Thus, the aim has been to test a large spectrum of variables ranging from clinical evaluation to laboratory biomarkers to identify which parameter would best predict all-cause in-hospital mortality in COVID-19 patients. Design observational study. Results Multivariate Cox regression analysis showed that each 5 years of increase in age corresponded to a hazard ratio (HR) of 1.28 (95% CI 1.00-1.65, P = .050); each increment of 803 ng/L of N-terminal pro-B-type natriuretic peptide (NT-proBNP) corresponded to a HR of 1.24 (95% CI 1.11-1.39, P < .001); each increment of 58 ng/L of interleukin (IL)-6 corresponded to a HR of 1.23 (95% CI 1.09-1.40, P < .001), and each increment of 250 U/L of lactate dehydrogenase (LDH) corresponded to a HR of 1.23 (95% CI 1.10-1.37, P < .001). According to the calculated cut-points for age (≥70 years), NT-proBNP (≥803 ng/L), IL-6 (≥58 ng/L) and LDH (≥371 U/L) when 2 out of these 4 were overcome, the HR was 2.96 (95% CI 1.97-4.45, P < .001). Conclusion In COVID-19 patients, besides age, the evaluation of three biochemical parameters, available in few hours after hospital admission can predict in-hospital mortality regardless of other comorbidities.read more
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The Association between TNF-α, IL-6, and Vitamin D Levels and COVID-19 Severity and Mortality: A Systematic Review and Meta-Analysis
TL;DR: IL-6 is an independent prognostic factor towards COVID-19 severity and mortality, and vitamin D has been discussed as a potential therapy for COVID, due to its immunomodulatory effects.
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Routine laboratory parameters, including complete blood count, predict COVID-19 in-hospital mortality in geriatric patients
Fabiola Olivieri,Jacopo Sabbatinelli,Anna Rita Bonfigli,Riccardo Sarzani,Piero Giordano,Antonio Cherubini,Roberto Antonicelli,Y. Rosati,Simona Del Prete,Mirko Di Rosa,Andrea Corsonello,Roberta Galeazzi,Antonio Domenico Procopio,Fabrizia Lattanzio +13 more
TL;DR: In this paper , the performance of selected routine laboratory biomarkers in improving the prediction of in-hospital mortality in 641 consecutive COVID-19 geriatric patients (mean age 86.6 ± 6.8) who were hospitalized at the INRCA hospital (Ancona, Italy).
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Echocardiographic assessment of the right ventricle in COVID-19: a systematic review.
Simone Ghidini,Simone Ghidini,Alessio Gasperetti,Dario Winterton,Marco Vicenzi,Marco Vicenzi,Mattia Busana,Giovanni Pedrazzini,Luigi Biasco,Gregorio Tersalvi +9 more
TL;DR: In this article, a systematic review presented the up-to-date sum of literature regarding right ventricle ultrasound assessment in patients with SARS-CoV-2 infected patients and discussed their relationship with pathophysiological mechanisms involved in COVID-19.
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Disentangling the impact of COVID-19 infection on clinical outcomes and preventive strategies in older persons: an Italian perspective
TL;DR: In this article , the authors discuss different Italian reports according to clinical settings and highlight the importance of GeroCovid Observational and GeroCoovid Vax, two large population-based prospective studies in Italy.
Disentangling the impact of COVID-19 infection on clinical outcomes and preventive strategies in older persons: an Italian perspective
Angela Marie Abbatecola,Raffaele Antonelli Incalzi,Alba Malara,Annapina Palmieri,Anna Di Lonardo,Gilda Borselli,Marcello Russo,Marianna Noale,Stefano Fumagalli,Pietro Gareri,Enrico Mossello,Caterina Trevisan,Stefano Volpato,Fabio Monzani,Alessandra Coin,Giuseppe Bellelli,Chukwuma Okoye,Susanna Del Signore,Gianluca Zia,Elisa Bottoni,Carmine Cafariello,Graziano Onder,GeroCovid Observational +22 more
References
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Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
TL;DR: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
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Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy.
Giacomo Grasselli,Giacomo Grasselli,Alberto Zangrillo,Alberto Zanella,Alberto Zanella,Massimo Antonelli,Massimo Antonelli,Luca Cabrini,Antonio Castelli,Danilo Cereda,Antonio Coluccello,Giuseppe Foti,Roberto Fumagalli,Giorgio Antonio Iotti,Nicola Latronico,Luca Lorini,Stefano Merler,Giuseppe Natalini,Alessandra Piatti,Marco Ranieri,Anna Mara Scandroglio,Enrico Storti,Maurizio Cecconi,Antonio Pesenti,Antonio Pesenti +24 more
TL;DR: Patients with coronavirus disease 2019 (COVID-19) requiring treatment in an intensive care unit (ICU) in the Lombardy region of Italy were characterized, including data on clinical management, respiratory failure, and patient mortality.
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Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China.
Shaobo Shi,Mu Qin,Bo Shen,Yuli Cai,Tao Liu,Fan Yang,Wei Gong,Xu Liu,Jinjun Liang,Qinyan Zhao,He Huang,Bo Yang,Congxin Huang +12 more
TL;DR: The association between cardiac injury and mortality in patients with COVID-19 was analyzed and it was found that patients with cardiac injury had a higher proportion of multiple mottling and ground-glass opacity in radiographic findings than those without cardiac injury.
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An inflammatory cytokine signature predicts COVID-19 severity and survival.
Diane Marie Del Valle,Seunghee Kim-Schulze,Hsin-Hui Huang,Noam D. Beckmann,Sharon Nirenberg,Bo Wang,Yonit Lavin,Talia H. Swartz,Deepu Madduri,Aryeh Stock,Thomas U. Marron,Hui Xie,Manishkumar Patel,Kevin Tuballes,Oliver Van Oekelen,Adeeb Rahman,Patricia Kovatch,Judith A. Aberg,Eric E. Schadt,Sundar Jagannath,Madhu Mazumdar,Alexander W. Charney,Adolfo Firpo-Betancourt,Damodara Rao Mendu,Jeffrey S. Jhang,David Reich,Keith Sigel,Carlos Cordon-Cardo,Marc Feldmann,Samir Parekh,Miriam Merad,Sacha Gnjatic +31 more
TL;DR: It is proposed that serum IL-6 and TNF-α levels should be considered in the management and treatment of patients with COVID-19 to stratify prospective clinical trials, guide resource allocation and inform therapeutic options.