Prognostic Value of Epithelial Growth Factor Receptor, Vascular Endothelial Growth Factor, E-Cadherin, and p120 Catenin in Resected Non-Small Cell Lung Carcinoma
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Cites background from "Prognostic Value of Epithelial Grow..."
...Importantly, interferon-γ, TGF-β, and VEGF levels were also greater in the blood, but not in the normal epithelium, of patients with only COPD than in non-COPD controls....
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...Systemic levels of TGF-β and VEGF were significantly greater in LC-COPD, LC, and COPD patients compared to non-COPD controls (Figs....
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...All LC patients showed a significant rise in VEGF levels compared to control subjects, both COPD and non-COPD (Fig....
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...Moreover, genetic variations of TGF-β [46] and systemic levels of TNF-α [47] and VEGF [48] were also shown to have potential implications in the survival of LC patients undergoing therapy....
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...In the current investigation, levels of the cytokines TNF-α, interferon-γ, TGF-β, and VEGF were greater in the normal bronchi of all patients with LC than in non-COPD controls....
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Cites result from "Prognostic Value of Epithelial Grow..."
...Among these 22 studies, 17 studies evaluated patients in Asian [14–17,19,20,23,25,26,29,31–36], five studies evaluated patients in Caucasian [18,21,27,28,30]....
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...Further subgroup analysis by race suggested that both Asian and Caucasian patients with reduced E-cadherin had a significant impact on OS (Asian: HR = 1.67, 95% CI = 1.42–1.96, p,0.001, I2 = 41.5%, P = 0.038; Caucasian: HR = 1.37, 95% CI = 1.12– 1.66, p = 0.002, I2 = 0.0%, P = 0.592)....
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References
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