Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient.
Ji Hoon Baang,Christopher Smith,Carmen Mirabelli,Andrew L Valesano,David M Manthei,Michael A. Bachman,Christiane E. Wobus,Michael D. Adams,Laraine Washer,Emily T. Martin,Adam S. Lauring +10 more
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TLDR
The patient’s lack of seroconversion and prolonged course illustrate the importance of humoral immunity in resolving SARS-CoV-2 infection and highlights challenges in managing immunocompromised hosts.Citations
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The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis.
Stephen A. Klassen,Jonathon W. Senefeld,Patrick W. Johnson,Rickey E. Carter,Chad C. Wiggins,Shmuel Shoham,Brenda J. Grossman,Jeffrey P. Henderson,James M. Musser,James M. Musser,Eric Salazar,Eric Salazar,William R. Hartman,Nicole M. Bouvier,Sean T. H. Liu,Liise Anne Pirofski,Sarah E. Baker,Noud van Helmond,R. Scott Wright,De Lisa Fairweather,Katelyn A. Bruno,Zhen Wang,Nigel Paneth,Arturo Casadevall,Michael J. Joyner +24 more
TL;DR: In this article, the effect of COVID-19 convalescent plasma on mortality was investigated in hospital patients with COVID19 and showed that early transfusion of higher titer plasma is associated with lower patient mortality.
Journal ArticleDOI
Long-Term Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infectiousness Among Three Immunocompromised Patients: From Prolonged Viral Shedding to SARS-CoV-2 Superinfection.
Hassan Tarhini,Amélie Recoing,Antoine Bridier-Nahmias,Mayda Rahi,Céleste Lambert,Pascale Martres,Jean-Christophe Lucet,Christophe Rioux,Donia Bouzid,Samuel Lebourgeois,Diane Descamps,Yazdan Yazdanpanah,Quentin Le Hingrat,François-Xavier Lescure,Benoit Visseaux +14 more
TL;DR: In this paper, the authors describe three deeply immunocompromised patients, each with different clinical evolutions, and observed the patients' epidemiological, clinical, and serological data, infectiousness using viral culture, and viral mutations accumulated over time.
Journal ArticleDOI
The emerging plasticity of SARS-CoV-2.
Journal ArticleDOI
Increased viral variants in children and young adults with impaired humoral immunity and persistent SARS-CoV-2 infection: A consecutive case series.
Thao T. Truong,Alex Ryutov,Utsav Pandey,Rebecca Yee,Lior Goldberg,Lior Goldberg,Deepa Bhojwani,Deepa Bhojwani,Paibel Aguayo-Hiraldo,Paibel Aguayo-Hiraldo,Benjamin A. Pinsky,Andrew Pekosz,Lishuang Shen,Scott D. Boyd,Oliver F. Wirz,Katharina Röltgen,Moiz Bootwalla,Dennis T. Maglinte,Dejerianne Ostrow,David Ruble,Jennifer H. Han,Jaclyn A. Biegel,Jaclyn A. Biegel,Maggie Li,ChunHong Huang,Malaya K. Sahoo,Pia S. Pannaraj,Pia S. Pannaraj,Maurice R.G. O'Gorman,Maurice R.G. O'Gorman,Alexander R. Judkins,Alexander R. Judkins,Xiaowu Gai,Xiaowu Gai,Jennifer Dien Bard,Jennifer Dien Bard +35 more
TL;DR: In this paper, the authors describe three patients with acute lymphoblastic leukemia who were persistently positive for SARS-CoV-2 by real-time polymerase chain reaction and found compelling evidence of ongoing replication and infectivity for up to 162 days from initial positive by subgenomic RNA, single-stranded RNA, and viral culture analysis.
Journal ArticleDOI
Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2.
Benjamin Israelow,Tianyang Mao,Jonathan Klein,Eric Song,Bridget L. Menasche,Saad B. Omer,Akiko Iwasaki,Akiko Iwasaki +7 more
TL;DR: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 160 million infections and more than 3 million deaths worldwide since 2003 as discussed by the authors.
References
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Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review.
W. Joost Wiersinga,Andrew Rhodes,Allen C. Cheng,Sharon J. Peacock,Sharon J. Peacock,Hallie C. Prescott +5 more
TL;DR: This review discusses current evidence regarding the pathophysiology, transmission, diagnosis, and management of COVID-19, the novel severe acute respiratory syndrome coronavirus 2 pandemic that has caused a worldwide sudden and substantial increase in hospitalizations for pneumonia with multiorgan disease.
Journal ArticleDOI
Predicting infectious severe acute respiratory syndrome coronavirus 2 from diagnostic samples
Jared Bullard,Jared Bullard,Kerry Dust,Duane J. Funk,Duane J. Funk,James E. Strong,James E. Strong,David C. Alexander,David C. Alexander,Lauren Garnett,Lauren Garnett,Carl Boodman,Alexander Bello,Alexander Bello,Adam Hedley,Zachary Schiffman,Zachary Schiffman,Kaylie Doan,Nathalie Bastien,Nathalie Bastien,Yan Li,Yan Li,Paul Van Caeseele,Paul Van Caeseele,Guillaume Poliquin,Guillaume Poliquin +25 more
TL;DR: SARS-CoV-2 Vero cell infectivity was only observed for RT-PCR Ct < 24 and STT < 8 days, suggesting Infectivity of patients with Ct >24 and duration of symptoms >8 days may be low.
Journal ArticleDOI
Ebola RNA Persistence in Semen of Ebola Virus Disease Survivors — Final Report
Deen Gf,Nathalie Broutet,Wenbo Xu,Barbara Knust,F. R. Sesay,McDonald Slr,Elizabeth Ervin,Jaclyn E. Marrinan,Philippe Gaillard,N. Habib,Hui Liu,Liu W,Anna Thorson,F. Yamba,Thomas Massaquoi,James F,Archchun Ariyarajah,Christine Ross,Kyle T. Bernstein,A. Coursier,John D. Klena,M. Carino,Wurie Ah,Yong Zhang,Dumbuya Ms,Neetu Abad,Idriss B,Wi T,Sarah D. Bennett,Davies T,Ebrahim Fk,Elissa Meites,Naidoo D,Smith Sj,Ongpin P,Tasneem Malik,Banerjee A,Bobbie R. Erickson,Yanmin Liu,Ke Xu,Aaron C. Brault,Kara N. Durski,Jörn Winter,Tara K. Sealy,Stuart T. Nichol,Lamunu M,Bangura J,Landoulsi S,Jambai A,Oliver Morgan,Guizhen Wu,Liang M,Su Q,Lan Y,Hao Y,Pierre Formenty,Ute Ströher,Foday Sahr +57 more
TL;DR: These data showed the long‐term presence of Ebola virus RNA in semen and declining persistence with increasing time after ETU discharge, as well as the risk of sexual transmission of EVD.
Journal ArticleDOI
Late Ebola virus relapse causing meningoencephalitis: a case report.
Michael Jacobs,Alison Rodger,David J. Bell,Sanjay Bhagani,Ian Cropley,Ana da Silva Filipe,Robert J. Gifford,Susan Hopkins,Joseph Hughes,Farrah Jabeen,Ingolfur Johannessen,Drosos E. Karageorgopoulos,Angie Lackenby,Rebecca Lester,Rebecca S. N. Liu,A MacConnachie,Tabitha Mahungu,Daniel Martin,Neal Marshall,Stephen Mepham,Richard J. Orton,Massimo Palmarini,Monika Patel,C. Perry,S. Erica Peters,Duncan Porter,David Ritchie,Neil D. Ritchie,R. Andrew Seaton,Vattipally B. Sreenu,Kate Templeton,Simon Warren,Gavin S. Wilkie,Maria Zambon,Robin Gopal,E. Thomson +35 more
TL;DR: It is shown that previously unanticipated, late, severe relapses of Ebola virus can occur, in this case in the CNS, and fundamentally redefines what is known about the natural history of Ebolairus infection.
Posted ContentDOI
Shedding of infectious virus in hospitalized patients with coronavirus disease-2019 (COVID-19): duration and key determinants
Jeroen J. A. van Kampen,David A. M. C. van de Vijver,Pieter L. A. Fraaij,Bart L. Haagmans,Mart M. Lamers,Nisreen M.A. Okba,Johannes P. C. van den Akker,Henrik Endeman,Diederik Gommers,Jan J. Cornelissen,Rogier A.S. Hoek,Menno M. van der Eerden,Dennis A. Hesselink,Herold J. Metselaar,Annelies Verbon,Jurriaan E. M. de Steenwinkel,Georgina I. Aron,Eric C. M. van Gorp,Sander van Boheemen,Jolanda J.C. Voermans,Charles A. Boucher,Richard Molenkamp,Marion Koopmans,Corine H. GeurtsvanKessel,Annemiek A. van der Eijk +24 more
TL;DR: Infectious virus shedding drops to undetectable levels below a viral RNA load threshold and once serum neutralizing antibodies are present, which warrants the use of quantitative viralRNA load assays and serological assays in test-based strategies to discontinue or de-escalate infection prevention and control precautions.
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