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Properties and applications of calcium hydroxide in endodontics and dental traumatology.

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TLDR
The properties and clinical applications of calcium hydroxide in endodontics and dental traumatology are reviewed including its antibacterial activity, antifungal activity, effect on bacterial biofilms, the synergism between calcium Hydroxide and other agents, its effects on the properties of dentine, the diffusion of hydroxyl ions through dentine and its toxicity.
Abstract
Calcium hydroxide has been included within several materials and antimicrobial formulations that are used in a number of treatment modalities in endodontics. These include, inter-appointment intracanal medicaments, pulp-capping agents and root canal sealers. Calcium hydroxide formulations are also used during treatment of root perforations, root fractures and root resorption and have a role in dental traumatology, for example, following tooth avulsion and luxation injuries. The purpose of this paper is to review the properties and clinical applications of calcium hydroxide in endodontics and dental traumatology including its antibacterial activity, antifungal activity, effect on bacterial biofilms, the synergism between calcium hydroxide and other agents, its effects on the properties of dentine, the diffusion of hydroxyl ions through dentine and its toxicity. Pure calcium hydroxide paste has a high pH (approximately 12.5-12.8) and is classified chemically as a strong base. Its main actions are achieved through the ionic dissociation of Ca2+ and OH- ions and their effect on vital tissues, the induction of hard-tissue deposition and the antibacterial properties. The lethal effects of calcium hydroxide on bacterial cells are probably due to protein denaturation and damage to DNA and cytoplasmic membranes. It has a wide range of antimicrobial activity against common endodontic pathogens but is less effective against Enterococcus faecalis and Candida albicans. Calcium hydroxide is also an effective anti-endotoxin agent. However, its effect on microbial biofilms is controversial.

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Citations
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Current perspectives of bio-ceramic technology in endodontics: calcium enriched mixture cement - review of its composition, properties and applications

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TL;DR: It is evident that biofilm formation is an ancient and integral component of the prokaryotic life cycle, and is a key factor for survival in diverse environments.
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The effects of surgical exposures of dental pulps in germ-free and conventional laboratory rats

TL;DR: The results indicate that the presence or absence of a microbial flora is the major determinant in the healing of exposed rodent pulps, even in the face of gross food impactions.
Book

Pathways of the Pulp

TL;DR: This chapter discusses Endodontic-Periodontic Interrelationships, Pulp Development, Structure and Function, Pulpal Reaction to Caries and Dental Procedures, and Digital Technologies in Endodonic Practice.
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TL;DR: This issue of the NJP, three articles on the prevalence of psychiatric disorders are published and depression appeared to be on a continuum where ‘‘proxy’’ measures such as impairment and need for treatment were associated with the intensity of depressed mood.
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Influence of infection at the time of root filling on the outcome of endodontic treatment of teeth with apical periodontitis

TL;DR: This study investigated the role of infection on the prognosis of endodontic therapy by following-up teeth that had had their canals cleaned and obturated during a single appointment, highlighting the importance of completely eliminating bacteria from the root canal system before obturation.
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