Figure 5. Analysis of oxycodone biodistribution in plasma and brain. A) Mean (±SEM) oxycodone concentrations in plasma, 30 min after injection of oxycodone (1.0 mg/kg, s.c.,) in TT and Oxy-TT groups (N=11 per group) of Cohort 1. B) Mean (±SEM) oxycodone concentrations in plasma at 15 or 30 min after injection of oxycodone (1.0 or 2.0 mg/kg, s.c.) in TT (N=10) and Oxy=TT (N=11; blood could not be obtained from one animal in this experiment) groups of Cohort 2. The insert shows that TT plasma levels at 30 min were twice as high after 2 mg/kg injected versus 1 mg/kg. C) Mean (±SEM) oxycodone concentrations in whole brain tissue at 30 min after injection of oxycodone (1.0 mg/kg, s.c.) in TT (N=10) and Oxy-TT (N=11) groups of Cohort 2. At the end of study in Cohort 1 (Week 29), D) plasma oxycodone levels were significantly higher in OxyTT rats compared to TT (N=5-6) rats 30 min after an injection of oxycodone (1.0-2.0 mg/kg, s.c.), whereas E) brain oxycodone levels showed no difference between OxyTT and TT rats. Post hoc tests: A significant difference between vaccine Groups is indicated with *.
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