Prophylactic vaccination protects against the development of oxycodone addiction
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Citations
Synthesis of (â)-Oxycodone
Anti-opioid vaccines
References
Ultra-low-dose naltrexone reduces the rewarding potency of oxycodone and relapse vulnerability in rats.
Safety and efficacy of an oxycodone vaccine: Addressing some of the unique considerations posed by opioid abuse
Effects of an Oxycodone Conjugate Vaccine on Oxycodone Self-Administration and Oxycodone-Induced Brain Gene Expression in Rats
Enhancing Efficacy and Stability of an Antiheroin Vaccine: Examination of Antinociception, Opioid Binding Profile, and Lethality
Escalation of intravenous self‐administration of methylone and mephedrone under extended access conditions
Related Papers (5)
Tolerance and cross-tolerance to the antinociceptive effects of oxycodone and the imidazoline I 2 receptor agonist phenyzoline in adult male rats
Frequently Asked Questions (2)
Q2. What future works have the authors mentioned in the paper "Prophylactic vaccination protects against the development of oxycodone self-administration" ?
Such consideration might include the likelihood of the individual requiring opioid medications in the near future and the availability of alternatives, as well as the relative risks of potentially using a higher dose of, e. g., oxycodone, in a very short course of pain management. This study was funded by grants from the USPHS R01 DA035281 ( M. A. T. ), R01 DA024705 ( M. A. T. ), UH3 DA041146 ( K. D. J. ) and F32 AI126628 ( C. S. H. ), which had no further input on the conduct of the work or the decision to publish results. Conversely it also underlines the potential need for multiple vaccines to address differing risk profiles with respect to abuse of multiple opioids, e. g. as modelled by Hwang and colleagues ( Hwang et al, 2018b ). This ratio is cut in half for seniors endorsing past month use, suggesting a change in relative risk from prescription to illicit opioids in the more-frequently using population which would potentially pivot health care priorities from single drug prophylaxis to multi-drug prevention/therapy depending on exposure history.