Journal ArticleDOI
Protection from H1N1 influenza virus infections in mice by supplementation with selenium: a comparison with selenium-deficient mice.
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TLDR
The data indicate that selenium supplementation may provide a feasible approach to improving the immune response to viral infections, such as lethal influenza infection.Abstract:
The present paper describes protective effects of supplemental selenium in mice infected with influenza virus. The effects of supplemental selenium on serum selenium levels, mortality, lung virus titers, and cytokine titers were investigated in mice inoculated intranasally with suspensions of influenza virus. Whereas the mortality of the virus-infected Se-deficient mice was 75%, along with a marked reduction in body weight, lower levels of TNF-α and IFN-γ and lower serum selenium concentrations, the mortality of mice maintained on feed containing 0.5 mg Se/kg in the form of sodium selenite was 25%.There were no significantly differences, however, in viral titer between the Se-adequate and the selenium-supplemented groups. The data indicate that selenium supplementation may provide a feasible approach to improving the immune response to viral infections, such as lethal influenza infection.read more
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The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities
TL;DR: Particular emphasis is given to how Se and selenoproteins are linked to redox signaling, oxidative burst, calcium flux, and the subsequent effector functions of immune cells, as well as the benefits and potential adverse effects of intervention with Se supplementation for various inflammatory or immune disorders.
Journal ArticleDOI
Nano-selenium and its nanomedicine applications: a critical review.
Bozena Hosnedlova,Marta Kepinska,Sylvie Skalickova,Carlos Fernandez,Branislav Ruttkay-Nedecky,Qiuming Peng,Mojmir Baron,Magdalena Melčová,Radka Opatrilova,Jarmila Zídková,Geir Bjørklund,Jiri Sochor,René Kizek,René Kizek +13 more
TL;DR: This review summarizes the survey of knowledge on selenium nanoparticles, their biological effects in the organism, advantages, absorption mechanisms, and nanotechnological applications for peroral administration and explores the possibilities of a more effective way of administration, especially in seenium-deficient organisms.
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Selenium, Selenoproteins and Viral Infection
TL;DR: The formal identification of viral selenoproteins in the genome of molluscum contagiosum and fowlpox viruses demonstrated the importance of selenocsteine in viral cycle.
Journal ArticleDOI
Selenium: an element for life
TL;DR: The evidence is at present conflicting as to whether Se supplementation is of benefit in patients with HT, though there are indications that it is advantageous in cases of mild/moderate Graves’ Orbitopathy and the role of Se in type 2 diabetes mellitus is ambiguous.
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Dietary Selenium in Adjuvant Therapy of Viral and Bacterial Infections
TL;DR: A recent review as mentioned in this paper provides an up-to-date overview on selenium in infectious diseases caused by viruses (e.g., HIV, IAV, hepatitis C virus, poliovirus, West Nile virus) and bacteria (i.e., M. tuberculosis, Helicobacter pylori).
References
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Iconographies supplémentaires de l'article : Mechanisms of nutrient modulation of the immune response
TL;DR: In this paper, the development of tolerance, control of inflammation, and response to normal mucosal flora are interrelated and linked to specific immune mechanisms, and Leptin is emerging as a cytokine-like immune regulator that has complex effects in both overnutrition and in the inflammatory response in malnutrition.
Journal ArticleDOI
Mechanisms of nutrient modulation of the immune response.
TL;DR: In this paper, the development of tolerance, control of inflammation, and response to normal mucosal flora are interrelated and linked to specific immune mechanisms, and Leptin is emerging as a cytokine-like immune regulator that has complex effects in both overnutrition and in the inflammatory response in malnutrition.
Journal ArticleDOI
Rapid genomic evolution of a non-virulent coxsackievirus B3 in selenium-deficient mice results in selection of identical virulent isolates.
TL;DR: To the best of the knowledge, this is the first report of a specific nutritional deficiency driving changes in a viral genome, permitting an avirulent virus to acquire virulence due to genetic mutation.
Journal ArticleDOI
Host nutritional selenium status as a driving force for influenza virus mutations.
George H. Brough,Songwei Wu,Donna L. Cioffi,Timothy Moore,Ming Li,Nicholas Dean,Troy Stevens +6 more
TL;DR: A role for endogenously expressed Trp1 in regulating a Ca2-selective current activated upon Ca2+ store depletion is supported.
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Host nutritional status: the neglected virulence factor.
TL;DR: It is shown that host nutritional status can influence not only the host response to the pathogen, but can also influence the genetic make-up of the viral genome.