Journal ArticleDOI
Protection from H1N1 influenza virus infections in mice by supplementation with selenium: a comparison with selenium-deficient mice.
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TLDR
The data indicate that selenium supplementation may provide a feasible approach to improving the immune response to viral infections, such as lethal influenza infection.Abstract:
The present paper describes protective effects of supplemental selenium in mice infected with influenza virus. The effects of supplemental selenium on serum selenium levels, mortality, lung virus titers, and cytokine titers were investigated in mice inoculated intranasally with suspensions of influenza virus. Whereas the mortality of the virus-infected Se-deficient mice was 75%, along with a marked reduction in body weight, lower levels of TNF-α and IFN-γ and lower serum selenium concentrations, the mortality of mice maintained on feed containing 0.5 mg Se/kg in the form of sodium selenite was 25%.There were no significantly differences, however, in viral titer between the Se-adequate and the selenium-supplemented groups. The data indicate that selenium supplementation may provide a feasible approach to improving the immune response to viral infections, such as lethal influenza infection.read more
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Journal ArticleDOI
The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities
TL;DR: Particular emphasis is given to how Se and selenoproteins are linked to redox signaling, oxidative burst, calcium flux, and the subsequent effector functions of immune cells, as well as the benefits and potential adverse effects of intervention with Se supplementation for various inflammatory or immune disorders.
Journal ArticleDOI
Nano-selenium and its nanomedicine applications: a critical review.
Bozena Hosnedlova,Marta Kepinska,Sylvie Skalickova,Carlos Fernandez,Branislav Ruttkay-Nedecky,Qiuming Peng,Mojmir Baron,Magdalena Melčová,Radka Opatrilova,Jarmila Zídková,Geir Bjørklund,Jiri Sochor,René Kizek,René Kizek +13 more
TL;DR: This review summarizes the survey of knowledge on selenium nanoparticles, their biological effects in the organism, advantages, absorption mechanisms, and nanotechnological applications for peroral administration and explores the possibilities of a more effective way of administration, especially in seenium-deficient organisms.
Journal ArticleDOI
Selenium, Selenoproteins and Viral Infection
TL;DR: The formal identification of viral selenoproteins in the genome of molluscum contagiosum and fowlpox viruses demonstrated the importance of selenocsteine in viral cycle.
Journal ArticleDOI
Selenium: an element for life
TL;DR: The evidence is at present conflicting as to whether Se supplementation is of benefit in patients with HT, though there are indications that it is advantageous in cases of mild/moderate Graves’ Orbitopathy and the role of Se in type 2 diabetes mellitus is ambiguous.
Journal ArticleDOI
Dietary Selenium in Adjuvant Therapy of Viral and Bacterial Infections
TL;DR: A recent review as mentioned in this paper provides an up-to-date overview on selenium in infectious diseases caused by viruses (e.g., HIV, IAV, hepatitis C virus, poliovirus, West Nile virus) and bacteria (i.e., M. tuberculosis, Helicobacter pylori).
References
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Journal ArticleDOI
Tumor Necrosis Factor Alpha Exerts Powerful Anti-Influenza Virus Effects in Lung Epithelial Cells
Sang Heui Seo,Robert G. Webster +1 more
TL;DR: TNF-α showed strong antiviral activity against avian, swine, and human influenza viruses, and the antiviral effect of TNF- α was greater than that of gamma or alpha interferon.
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Selenium deficiency-induced growth retardation is associated with an impaired bone metabolism and osteopenia.
TL;DR: It is shown that growth retardation induced by selenium deficiency is associated with impaired bone metabolism and osteopenia in second‐generation selenia‐deficient rats.
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Benign human enterovirus becomes virulent in selenium-deficient mice.
Melinda A. Beck,Peter C. Kolbeck,Lisa H. Rohr,Qing Shi,Virginia C. Morris,Orville A. Levander +5 more
TL;DR: It is reported that a cloned and sequenced amyocarditic coxsackievirus B3 (CVB3/0), which causes no pathology in the hearts of Se‐adequate mice, induces extensive cardiac pathology in Se‐deficient mice, suggesting mutation of the virus to a virulent genotype.
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Effect of micronutrient status on natural killer cell immune function in healthy free-living subjects aged ≥90 y
Giovanni Ravaglia,Paola Forti,Fabiola Maioli,Luciana Bastagli,Andrea Facchini,Erminia Mariani,Lucia Savarino,S. Sassi,Domenico Cucinotta,Giorgio Lenaz +9 more
TL;DR: The hypothesis that individual micronutrients may affect the number and function of NK cells in old age is strengthened, as the study confirms the high prevalence ofmicronutrient deficiencies in healthy and apparently well-nourished persons aged >/=90 y.
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In vivo anti-influenza virus activity of an immunomodulatory acidic polysaccharide isolated from Cordyceps militaris grown on germinated soybeans.
TL;DR: The results demonstrated that APS might have beneficial therapeutic effects on influenza A virus infection at least in part by modulation of the immune function of macrophages.