Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation
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Cites background from "Protection from pulmonary ischemia-..."
...In lung inflammation, adenosine promotes the cellular response to hypoxia [88] and the reduction of extravasation of proteins and cytokines in the alveolus with decreased infiltrated neutrophils [89]....
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References
857 citations
"Protection from pulmonary ischemia-..." refers background in this paper
...It is known that neutrophils progressively infiltrate the transplanted lung after reperfusion and contribute to injury by releasing oxygen free radicals [2]....
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...Background Ischemia-reperfusion (IR)-induced lung injury remains the major cause of primary graft failure after lung transplantation [1,2]....
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680 citations
"Protection from pulmonary ischemia-..." refers background in this paper
...The attenuation of IR injury by A2AAR activation is postulated to involve a purinergic regulatory process whereby the A2AAR coupled to a stimulatory G protein leads to an increase in cyclic adenosine monophosphate (cAMP), thereby resulting in reduced cytokine release and inactivation of inflammatory cells [30,31]....
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650 citations
"Protection from pulmonary ischemia-..." refers background in this paper
...Adenosine receptor sub-classification has shown specifically that activation of A2AAR produces antiinflammatory responses and prevents leukocyte adhesion [18,19]....
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585 citations
"Protection from pulmonary ischemia-..." refers background in this paper
...Atelectasis and reexpansion has been shown to induce injury involving edema, free radical generation, and apoptosis [33,34]....
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412 citations
"Protection from pulmonary ischemia-..." refers background in this paper
...Pulmonary IR injury also entails the induction of pro-inflammatory cytokines and chemokines [9,10], and the contribution of TNF-α, IL-1β, IL-6 and KC (CXCL1) in the genesis and progression of lung IR injury has been demonstrated [5,11,12]....
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