Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation
Citations
256 citations
Cites background from "Protection from pulmonary ischemia-..."
...A2A receptor agonists attenuated cardiac dysfunction arising from pulmonary ischemia-reperfusion injury (Reece et al., 2005; Ellman et al., 2008; Gazoni et al., 2008; Sharma et al., 2009)....
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113 citations
Cites background from "Protection from pulmonary ischemia-..."
...These include reperfusion injury in the heart [11], liver [13], kidney [9], and lung [6]....
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110 citations
108 citations
Cites background from "Protection from pulmonary ischemia-..."
...As in other tissues, A2AAR activation protects against inflammatory tissue damage in the lung caused by IRI[90,112,113]....
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75 citations
References
176 citations
"Protection from pulmonary ischemia-..." refers background or methods or result in this paper
...We have previously demonstrated that alveolar macrophage activation [4] and alveolar type II epithelial cell activation [5] are associated with the induction of lung IR injury....
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...For this study, we used an isolated, buffer-perfused mouse lung system (Hugo Sachs Elektronik, March-Huggstetten, Germany) as previously described by our laboratory [4]....
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...Previous studies from our group and others have demonstrated a significant role of alveolar macrophages in the initiation of lung IR injury [4,46,47]....
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...We have previously shown that a significant number of marginated neutrophils are retained in buffer-perfused lungs [4]....
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...We have previously demonstrated the presence of marginated neutrophils in buffer-perfused mouse lungs [4]....
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145 citations
"Protection from pulmonary ischemia-..." refers background in this paper
...The pro-inflammatory cascade in lung IR injury involving TNF-α has also been previously documented by our group and others [12,49,50]....
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140 citations
"Protection from pulmonary ischemia-..." refers background in this paper
...It is plausible that activation of other adenosine receptors (A1, A2B and A3), which are all expressed in the lung [40], may have significant, anti-inflammatory roles in the pathogenesis of IR....
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138 citations
"Protection from pulmonary ischemia-..." refers background in this paper
...It is plausible that activation of other adenosine receptors (A1, A2B and A3), which are all expressed in the lung [40], may have significant, anti-inflammatory roles in the pathogenesis of IR. For example, it is well documented that A1AR plays a role in protecting the heart [41] and kidney [ 42 ] against IR injury....
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136 citations
"Protection from pulmonary ischemia-..." refers background in this paper
...Adenosine receptor sub-classification has shown specifically that activation of A2AAR produces antiinflammatory responses and prevents leukocyte adhesion [18,19]....
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