Protection from renal ischemia-reperfusion injury by the 2-methylaminochroman U83836E
Elena De Vecchi,Lorenzo Lubatti,Claudio Beretta,Stefano Ferrero,Paola Rinaldi,Marzia Galli Kienle,Rinaldo Trazzi,Rita Paroni +7 more
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TLDR
There is a protective effect of U83836E in ischemia-reperfusion injury, in that tissue damage due to oxidative stress is reduced, thus ameliorating renal function impairment.About:
This article is published in Kidney International.The article was published on 1998-09-01 and is currently open access. It has received 27 citations till now. The article focuses on the topics: Kidney & Kidney disease.read more
Citations
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Journal ArticleDOI
Reactive oxygen species and acute renal failure
Karl A. Nath,Suzanne M. Norby +1 more
TL;DR: Evidence indicating that the inordinate or aberrant generation of reactive oxygen species (ROS) may contribute to the initiation and maintenance of ATN is reviewed, and the possibility that ROS may participate in the recovery phase of ATn is raised.
Journal ArticleDOI
Mitochondria-Targeted Peptide Accelerates ATP Recovery and Reduces Ischemic Kidney Injury
Hazel H. Szeto,Shaoyi Liu,Yi Soong,Dunli Wu,Shaun Darrah,Feng Ying Cheng,Zhihong Zhao,Michael Ganger,Clara Y. Tow,Surya V. Seshan +9 more
TL;DR: Treatment with SS-31 protected mitochondrial structure and respiration during early reperfusion, accelerated recovery of ATP, reduced apoptosis and necrosis of tubular cells, and abrogated tubular dysfunction, suggesting that it may protect against ischemic renal injury.
Journal ArticleDOI
Resveratrol, a polyphenol found in wine, reduces ischemia reperfusion injury in rat kidneys.
Luca Giovannini,Massimiliano Migliori,Biancamaria Longoni,Dipak K. Das,A. A. E. Bertelli,Vincenzo Panichi,C Filippi,Aldo Bertelli +7 more
TL;DR: The results suggest that resveratrol reduced the renal ischemia reperfusion injury through a nitric oxide-dependent mechanism.
Journal ArticleDOI
Oxidative stress and reactive nitrogen species generation during renal ischemia.
TL;DR: The data clearly demonstrate that oxidative stress and RNS generation occur in the kidney during ischemia, and indicates that reactive nitrogen species (RNS) formation during I-R injury is driven by oxidant stress.
Journal ArticleDOI
Oxidative stress and kidney dysfunction due to ischemia/reperfusion in rat: Attenuation by dehydroepiandrosterone
Manuela Aragno,Juan Carlos Cutrin,Raffaella Mastrocola,Maria-Giulia Perrelli,F Restivo,Giuseppe Poli,Oliviero Danni,Giuseppe Boccuzzi +7 more
TL;DR: Rats supplemented with DHEA and subjected to I/R had reduced pro-oxidant state, oxidative damage, and improved renal functionality, indicating an attenuation of oxidative injury and dysfunctions mediated by I-R.
References
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Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation.
TL;DR: Two representative compounds from a novel chemical series of potent inhibitors of lipid peroxidation are described and one of the compounds, U74500A, may act as a membrane localized chelator of iron.
Journal ArticleDOI
The morphology of "acute tubular necrosis" in man: analysis of 57 renal biopsies and a comparison with the glycerol model.
TL;DR: The glycerol model of acute renal failure in the rabbit was found to differ in several significant ways from ATN in man and may have an entirely different pathogenesis.
Journal ArticleDOI
The cell biology of ischemic renal injury
TL;DR: Most currently available data are pertinent to understanding the early events at the tubule cell level, and this information will necessarily comprise most of the review.
Journal ArticleDOI
21-Aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils.
TL;DR: It is shown that U74006F can improve survival and attenuate neuronal necrosis in a severe brain ischemia model and comparison of neuronal densities in the ischemic hemisphere with those in the contralateral nonischemic hemisphere revealed significant neuronal preservation.
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Aslı Korkmaz,Diirdane Kolankaya +1 more