Journal ArticleDOI
Protective effects of amide constituents from the fruit of Piper chaba on D-galactosamine/TNF-α-induced cell death in mouse hepatocytes
Hisashi Matsuda,Kiyofumi Ninomiya,Kiyofumi Ninomiya,Toshio Morikawa,Toshio Morikawa,Daisuke Yasuda,Itadaki Yamaguchi,Masayuki Yoshikawa +7 more
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TLDR
A principal amide constituent, piperine, dose-dependently inhibited increase in serum GPT and GOT levels at doses of 2.5-10 mg/kg (p.o.) in D-GalN/LPS-treated mice, and this inhibitory effect was suggested to depend on the reduced sensitivity of hepatocytes to TNF-alpha.About:
This article is published in Bioorganic & Medicinal Chemistry Letters.The article was published on 2008-03-15. It has received 89 citations till now. The article focuses on the topics: Piper chaba & Piperine.read more
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Biological role of Piper nigrum L. (Black pepper): A review
TL;DR: A review based on the biological role of Piper nigrum can provide that the peppercorn or other parts can be use as crude drug for various diseases while the secondary metabolites such as piperine can be used for specific diseases.
Journal ArticleDOI
A Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers
Dudhatra Gb,S.K. Mody,Awale Mm,H.B. Patel,Chirag M Modi,Avinash Kumar,Divyesh R. Kamani,Bhavesh N. Chauhan +7 more
TL;DR: This paper clearly indicates that scientific researchers and pharmaceutical industries have to give emphasis on experimental studies to find out novel active principles from such a vast array of unexploited plants having a role as a bioavailability and bioefficacy enhancer.
Journal ArticleDOI
A Review on Therapeutic Potential of Piper nigrum L. (Black Pepper): The King of Spices
Zoheir A. Damanhouri,Aftab Ahmad +1 more
TL;DR: The current review article is aimed to provide an updated literature review on recent advancement of pharmacognosy, chemistry and pharmacological activities of Piper nigrum L.
Journal ArticleDOI
Role of herbal bioactives as a potential bioavailability enhancer for Active Pharmaceutical Ingredients.
Ajazuddin,Amit Alexander,Azra Qureshi,Leena Kumari,Pramudita Vaishnav,Mukesh Sharma,Swarnlata Saraf,Shailendra Saraf +7 more
TL;DR: Herbal bioenhancers are easily available, safe, free from side effects, minimizes drug toxicity, shortens the duration of treatment, lowers the drug resistance problems and minimizes the cost of treatment.
Journal ArticleDOI
Piperidine alkaloids from Piper retrofractum Vahl. protect against high-fat diet-induced obesity by regulating lipid metabolism and activating AMP-activated protein kinase.
TL;DR: It is demonstrated that PRPAs attenuate HFD-induced obesity by activating AMPK and PPARδ, and regulate lipid metabolism, suggesting their potential anti-obesity effects.
References
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Journal ArticleDOI
Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice.
TL;DR: It is concluded that tumor necrosis factor alpha is likely to act as a final mediator of endotoxin action in a sequence of events which includes formation of leukotriene D4 and reactive oxygen species.
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Tumor necrosis factor alpha mediates lethal activity of killed gram-negative and gram-positive bacteria in D-galactosamine-treated mice.
TL;DR: The data show that TNF-alpha is a common endogenous mediator of the lethal activity of gram-negative and gram-positive bacteria, which may exhibit lethal effects in sensitized animals.
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Tumor Necrosis Factor-induced Toxic Liver Injury Results from JNK2-dependent Activation of Caspase-8 and the Mitochondrial Death Pathway
TL;DR: Toxic liver injury is associated with JNK over-activation and mediated by JNK2 promotion of caspase-8 activation and the TNF mitochondrial death pathway through a mechanism independent of c-Jun kinase activity.
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Inhibitory effect and action mechanism of sesquiterpenes from Zedoariae Rhizoma on D-galactosamine/lipopolysaccharide-induced liver injury.
TL;DR: Hepatoprotective sesquiterpenes were isolated from the aqueous acetone extract of Zedoariae Rhizoma, the rhizome of Curcuma zedoaria ROSCOE and found to show potent protective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced acute liver injury in mice.
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Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins.
TL;DR: Five new dammarane-type triterpene saponins, notoginsenosides-O, -P, -Q, -S, and -T, were isolated together with nine known protopanaxadiol oligoglycosides and elucidated on the basis of chemical and physicochemical evidence.
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Immunomodulatory and antitumor activity of Piper longum Linn. and piperine.
E.S Sunila,G Kuttan +1 more