Protein profiles in zebrafish (Danio rerio) embryos exposed to perfluorooctane sulfonate.
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TLDR
Overall, proteomic analysis using zebrafish embryos serves as an in vivo model in environmental risk assessment and provides insight into the molecular events in PFOS-induced developmental toxicity.About:
This article is published in Toxicological Sciences.The article was published on 2009-08-01 and is currently open access. It has received 82 citations till now. The article focuses on the topics: Steroid metabolic process & Proteomics.read more
Citations
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Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance.
TL;DR: A fusion of basic and translational research is needed to validate or refine existing risk assessments and regulatory standards for this common mycotoxin.
Journal ArticleDOI
The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos
Xiongjie Shi,Bingsheng Zhou +1 more
TL;DR: It is found that coexposure with sulforaphane, an Nrf2 activator, could significantly protect against PFOS-induced ROS generation, whereas inhibition of MAPKs did not exhibit significant effects on PFos-induced HO-1 gene expression and ROS production.
Journal ArticleDOI
Bioaccumulation of Perfluorinated Alkyl Acids: Observations and Models
Carla A. Ng,Konrad Hungerbühler +1 more
TL;DR: It is concluded that the two prevailing hypotheses for the mechanisms that control the bioaccumulation of perfluorinated alkyl acids need not be mutually exclusive, but that protein interactions are needed to explain some important features of PFAA bio Accumulation.
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Physicochemical Properties and Aquatic Toxicity of Poly- and Perfluorinated Compounds
TL;DR: In this article, the authors summarize the data available for the physicochemical properties and aquatic toxicity of poly-and perfluorinated compounds (PFCs) in order to have a clear overview of the available data.
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Chronic zebrafish PFOS exposure alters sex ratio and maternal related effects in F1 offspring
Mingyong Wang,Jiangfei Chen,Kuanfei Lin,Yuanhong Chen,Wei Hu,Robert L. Tanguay,Changjiang Huang,Qiaoxiang Dong +7 more
TL;DR: It is demonstrated that chronic exposure to PFOS adversely impacts embryonic growth, reproduction, and subsequent offspring development.
References
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Journal ArticleDOI
Global distribution of perfluorooctane sulfonate in wildlife.
TL;DR: Fish-eating, predatory animals such as mink and bald eagles contained concentrations of PFOS that were greater than the concentrations in their diets, suggesting that PFOS can bioaccumulate to higher trophic levels of the food chain.
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Annexins: from structure to function.
Volker Gerke,Stephen E. Moss +1 more
TL;DR: Although annexins lack signal sequences for secretion, some members of the family have also been identified extracellularly where they can act as receptors for serum proteases on the endothelium as well as inhibitors of neutrophil migration and blood coagulation.
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Molecular Biology of Steroid Hormone Synthesis
TL;DR: Five groups of steroid hormones are generally recognized according to their physiological behavior: mineralocorticoids, which instruct the renal tubules to retain sodium; glucocortics, which are named for their carbohydratemobilizing properties but have many other effects as well; estrogens, which induce female secondary sexual characteristics; progestins, which is essential for reproduction; and androgens, who induce male secondarySexual characteristics.
REVIEW Human Sulfotransferases and Their Role in Chemical Metabolism
Niranjali Gamage,Amanda C. Barnett,Nadine Hempel,Ronald G. Duggleby,Kelly F. Windmill,Jennifer L. Martin,Michael E. McManus +6 more
TL;DR: SULTs have a wide tissue distribution and act as a major detoxification enzyme system in adult and the developing human fetus as mentioned in this paper, and they are also capable of bioactivating procarcinogens to reactive electrophiles.
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Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. II: postnatal evaluation.
Christopher Lau,Julie R. Thibodeaux,Roger G. Hanson,John M. Rogers,Brian E. Grey,Mark E. Stanton,John L. Butenhoff,Lisa A. Stevenson +7 more
TL;DR: It is indicated that in utero exposure to PFOS severely compromised postnatal survival of neonatal rats and mice, and caused delays in growth and development that were accompanied by hypothyroxinemia in the surviving rat pups.