Proteinase-activated receptors
Citations
1,310 citations
1,036 citations
Cites background from "Proteinase-activated receptors"
...The mechanisms of PAR1 and PAR2 signaling have been extensively investigated and reviewed (89, 182)....
[...]
...The characteristics of PAR APs and their utility as templates for design of antagonists have been recently reviewed in detail (182) and are only summarized here....
[...]
686 citations
534 citations
511 citations
References
10,651 citations
"Proteinase-activated receptors" refers background in this paper
...…the production and release of promitogenic factors, such as PDGF and ET-1 through induction of PDGF and ET-1 prepro mRNA (Daniel et al., 1986; Yanagisawa et al., 1988; Garcia et al., 1993; Golden et al., 1998) and also regulates the subsequent release of these factors, in particular ET-1…...
[...]
2,992 citations
"Proteinase-activated receptors" refers background in this paper
...Mutation of the N terminus identified the presence of a hirudin-like domain within region 51–63 that was essential for high affinity binding and the potent effects of thrombin (Vu et al., 1991b)....
[...]
...Furthermore, responses to thrombin were found to be blocked by the thrombin antagonists hirudin and hirugen, a hirudin-derived peptide (Vu et al., 1991a) indicative of the thrombin-specific nature of the cloned receptor....
[...]
...In 1991, Coughlin and colleagues (Vu et al., 1991a) used a dilution cloning approach in an attempt to isolate the cDNA encoding the thrombin receptor....
[...]
...Mutation of this residue, Arg41 to Ala, rendered the receptor insensitive to stimulation when expressed in oocytes (Vu et al., 1991a), whereas a peptide mimicking the new amino terminus created by cleavage at Arg41, SFLLRNPNDKYEPF (TRAP-14), was able to activate both wild-type and mutant receptors....
[...]
...A mutant receptor with the LDPR/S site replaced by an enterokinase site was fully responsive to enterokinase, suggesting no require- ment for an additional mechanism of activation other than that initially proposed (Vu et al., 1991b)....
[...]
2,354 citations
"Proteinase-activated receptors" refers background in this paper
...Such is the rapidly expansive nature of the field; the reader is directed to a number of excellent recent shorter reviews that will complement this current work (Grand et al., 1996; Hollenberg, 1996; Dery et al., 1998; Cocks and Moffatt, 2000; Coughlin, 2000)....
[...]
2,045 citations
"Proteinase-activated receptors" refers background in this paper
...In addition, thrombin also mediates the translocation of P-selectin and CD40 ligand to the plasma membrane, which facilitate the binding of platelets to endothelial cells (Stenberg et al., 1985; Henn et al., 1998)....
[...]
...Thrombin released from platelets stimulates the release of von Willebrand factor, cell surface redistribution of P-selectin, and increased expression of tissue factor and adhesion molecules, ICAM-1, VCAM-1, and E-selectin (Hattori et al., 1989; Bartha et al., 1993; Henn et al., 1998)....
[...]
1,803 citations
"Proteinase-activated receptors" refers background in this paper
...Thrombin was originally identified as a trypsin-like serine protease, produced from prothrombin by the action of factor Xa, which mediated the formation of fibrin, the fibrous matrix of blood clots, from fibrinogen (Davie et al., 1991; Stubbs and Bode, 1993)....
[...]