Proteoglycans in cancer biology, tumour microenvironment and angiogenesis
Citations
1,379 citations
Cites background from "Proteoglycans in cancer biology, tu..."
...mainly, through their GAG side chains participating in several cell functional properties, such as cell signaling, proliferation, migration, differentiation, apoptosis and adhesion [14, 16-19]....
[...]
...PGs and GAGs play important roles in normal physiology and development of various diseases since their biosynthesis is markedly modified during ECM remodeling in all pathologies [14, 16-19]....
[...]
856 citations
Cites background from "Proteoglycans in cancer biology, tu..."
...Perlecan is a complex regulator of vascular biology and tumor angiogenesis [33,140,141] by performing a dual function: via the N-terminal HS chains, perlecan is pro-angiogenic [96] by binding and presenting VEGFA and various FGFs to their cognate receptors [33,141– 152]....
[...]
308 citations
289 citations
Cites background from "Proteoglycans in cancer biology, tu..."
...Multifunctional involvement of proteoglycans makes them both potential targets for cancer remedies and novel antitumoral therapeutic agents (57, 58)....
[...]
...Small leucine-rich proteoglycans, such as decorin and lumican, act as tumor repressors (57)....
[...]
288 citations
References
4,613 citations
"Proteoglycans in cancer biology, tu..." refers background in this paper
...Domain V of perlecan bound with high affinity to the non collagenous NC1 domain of collagen XVIII [76] which includes the well-established angiogenic inhibitor endostatin [77]....
[...]
2,894 citations
"Proteoglycans in cancer biology, tu..." refers background in this paper
...This is interesting because the vascular abnormalities observed in the perlecan morphants are similar to those observed in VEGFA morphants [59], null mutants of VEGFR2 [60] or phospholypase C 1 [61], a downstream effector of VEGFR2 [62, 63]....
[...]
...Moreover, a significant proportion of the perlecan morphants could be rescued by intra-embryonic injections of human VEGFA, suggesting that perlecan acts upstream of VEGFA/VEGFR2 axis [58]....
[...]
...SHP-1 then dephosphorylates a number of RTKs including VEGFR2, thereby blocking endothelial cell migration, survival and proliferation....
[...]
...Concomitantly, there is vascular expression of VEGFR2 and sustained VEFGR2 activation, suggesting that, like in the zebrafish model described above, perlecan might represent a potent reservoir of growth factors that can be presented to and utilized by VEGFR2 [67]....
[...]
...This concept is further supported by the discovery that heparan sulphate proteoglycans in trans can potentiate VEGFR2 signalling and thus angiogenesis by evoking a sustained signal transduction due to heparan sulphate-dependent trapping of the active VEGFR2 signalling complex [69]....
[...]
1,660 citations
"Proteoglycans in cancer biology, tu..." refers background in this paper
...Both -catenin and Myc translocate to the nucleus where they activate a large number of genes including Myc itself [240, 241], thereby establishing a positive feedback loop that favours growth and survival (Fig....
[...]
1,560 citations
1,494 citations
"Proteoglycans in cancer biology, tu..." refers background in this paper
...It was subsequently found that decorin secreted by the transgenic CHO cells bound with high affinity to TGF- thereby blocking the growth-stimulatory activity of the growth factor [196]....
[...]