Proteomic analysis of the inhibitory effect of epigallocatechin gallate on lipid accumulation in human HepG2 cells
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"Proteomic analysis of the inhibitor..." refers background or methods in this paper
...[6], and reduced the development of experimental nonalcoholic steatohepatitis through its effect on lipid metabolism [7]....
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...The cells were lysed in lysis buffer (7 M urea, 2 M thiourea, 4% [w/v] CHAPS, 65 mM DTT, 2% [v/v] Bio-Lyte pH [3-10], 2% protease inhibitor cocktail), mixed by vortexing, kept in an ice bath for 2 h, then sonicated in an ice bath....
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518 citations
"Proteomic analysis of the inhibitor..." refers background in this paper
...PAF is a potent pro-inflammatory phospholipid that activates cells involved in inflammation and stimulates ROS generation [41-43]....
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493 citations
"Proteomic analysis of the inhibitor..." refers background in this paper
...Prior studies have found that a reduction in oxidative enzymes is correlated with a reduced capacity for lipid oxidation and increased risk for obesity [35,36]....
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487 citations
"Proteomic analysis of the inhibitor..." refers background in this paper
...Activation of AMPK in liver and skeletal muscle leads to the stimulation of fatty acid oxidation and inhibition of lipogenesis, glucose production and protein synthesis [30,31]....
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