Proteomic analysis of the inhibitory effect of epigallocatechin gallate on lipid accumulation in human HepG2 cells
Citations
54 citations
37 citations
25 citations
17 citations
11 citations
References
332 citations
"Proteomic analysis of the inhibitor..." refers background in this paper
...Succinate dehydrogenase (SDH or ubiquinone) is an enzyme that controls the transcription of metabolism-related genes in mitochondria and promotes metabolism of glucose and lipids [32,33]....
[...]
320 citations
"Proteomic analysis of the inhibitor..." refers background or methods in this paper
...Studies have suggested that (−)-epigallocatechin-3-gallate (EGCG), the most abundant catechin found in green tea, could effectively reduce body weight and tissue and blood fat accumulation [4,5]....
[...]
...The cells were lysed in lysis buffer (7 M urea, 2 M thiourea, 4% [w/v] CHAPS, 65 mM DTT, 2% [v/v] Bio-Lyte pH [3-10], 2% protease inhibitor cocktail), mixed by vortexing, kept in an ice bath for 2 h, then sonicated in an ice bath....
[...]
300 citations
288 citations
"Proteomic analysis of the inhibitor..." refers background in this paper
...Several studies reported that an increase in reactive oxygen species (ROS) could lead to AMPK activation [27,28]....
[...]
271 citations
"Proteomic analysis of the inhibitor..." refers background in this paper
...Plateletactivating factor acetylhydrolase (PAFAH), a unique member of the phospholipase A2 superfamily, is characterized by its ability to specifically hydrolyze plateletactivating factor (PAF) and glycerophospholipids [40]....
[...]