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Journal Article

Proximate Composition, Free Radical Scavenging and NOS Activation Properties of Ramaria aurea

28 Oct 2012-Research Journal of Pharmacy and Technology (A and V Publication)-Vol. 5, Iss: 11, pp 1421-1427
TL;DR: The present results revealed that this mushroom might be utilized as a promising dietary supplement for patients with diabetes, obesity, atherosclerosis, high blood pressure, etc.
Abstract: Mushrooms are a high valued source of nutrition and mineral constituents which are of paramount importance in the present age. Here, different nutritional parameters, i.e., protein, carbohydrate, fat, amino acid, crude fiber and mineral contents of Ramaria aurea were evaluated. Results showed that this mushroom had significant amount of carbohydrate, protein, free amino acids and crude fiber where as low amount of fat signifies its importance as diet for the sufferers of diabetes, obesity, atherosclerosis, high blood pressure, etc. Mineral analyses showed that this mushroom was good source of calcium, magnesium, potassium, phosphorous and iron. Cellular damage caused by reactive oxygen species has been implicated in several diseases and hence antioxidants have significant importance in human health. The cold water, hot water and ethanolic extract of Ramaria aurea were analyzed for their antioxidant activities in different systems namely inhibition of lipid peroxidation, DPPH free radical and hydroxyl radical scavenging activities. The antioxidant activities among the three different extracts, ethanolic extract showed the strongest antioxidant activities in all the test systems. Furthermore, crude, boiled and ethanolic extracts also increased significantly nitric oxide production (319.1, 383.4 and 605.8 pmol NO produced/mg dry wt/h respectively) over the control. The present results revealed that this mushroom might be utilized as a promising dietary supplement.
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TL;DR: This review compiles the most current studies on foods that help fight metabolic syndrome and the scientific evidences to support their use, including functional fats, digestive enzymes inhibitors, different fruits, specific vegetables, grains, legumes, herbs and spices.
Abstract: Metabolic syndrome is a condition of at least three of the cardiovascular risk factors: obesity, excessive visceral fat storage, dyslipidemia, hypertension and hyperglycaemia or Type 2 diabetes. It is a state of insulin resistance, oxidative stress and chronic inflammation. Cardiovascular disease is the highest cause of death globally. Certain dietary components and over 800 plants help prevent or moderate metabolic syndrome by assisting the body homeostasis mechanisms. This review compiles the most current studies on foods that help fight metabolic syndrome and the scientific evidences to support their use. This includes functional fats, digestive enzymes inhibitors, various beverages, different fruits, specific vegetables, grains, legumes, herbs and spices that can reduce cardiovascular disease risk, through several cellular mechanisms.

184 citations


Cites background from "Proximate Composition, Free Radical..."

  • ...They have low fat content and are a good source of carbohydrate, protein, free amino acids, dietary fiber, antioxidants, calcium, magnesium, potassium, phosphorous and iron (Rai & Acharya, 2012)....

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Journal Article
TL;DR: This review will discuss about ROS, their harmful effect on biological systems and antioxidant property as well as comparative antioxidant activity of mushrooms with special attention on some popular edible and medicinal ones.
Abstract: Reactive oxygen species (ROS) are induced by various endogenous and exogenous sources. Although almost all organisms are equipped with antioxidant defence systems, which are often inadequate to completely prevent oxidation stress-induced damage. Therefore, antioxidant supplements or natural products containing antioxidants may be used to reduce oxidative damage to the human body. Mushrooms have been part of the normal human diet for thousands of years and in recent times, the amounts consumed have risen greatly involving a large number of species. The main bioactive components of mushroom are phenolic compounds (phenolic acid and flavonoids), tocopherols, ascorbic acid, carotenoids. Polysaccharides are also important biologically active ingredients. The higher antioxidant activity is reflected by lower EC50 value. Austreus hygrometricus, Fistulina hepatica, Phellinus linteus, Pleorotus squarrosulus, Polyporus grammocephalus, Macrocybe gigantea show higher antioxidant potential. This review will discuss about ROS, their harmful effect on biological systems and antioxidant property as well as comparative antioxidant activity of mushrooms with special attention on some popular edible and medicinal ones.

94 citations

01 Jan 2013
TL;DR: Administration of extracts orally reduced the level of blood glucose in diabetic mice treated with alloxan and showed better tolerance to glucose, and the treatment with extract furthermore showed betterolerance to glucose.
Abstract: Objective: All over the whole world, mushrooms have been cherished for thousands of years both as medicine and as food. In the present study, we report the hypoglycemic effects of ethanolic extract of Astraeus hygrometricus (Pers.) Morg. (Astraeceae), in alloxan-induced diabetic mice. Methods: A. hygrometricus ethanolic extract was administrated by oral route, and levels of blood glucose and body weight were measured. In a separate set of mice, an oral glucose tolerance test (OGTT) was conducted. Results: Administration of extracts orally reduced the level of blood glucose in diabetic mice treated with alloxan, tested subsequent to acute (24 hours) and subacute (28 days) administration. The treatment with extract furthermore showed better tolerance to glucose.

34 citations


Cites background from "Proximate Composition, Free Radical..."

  • ...Mushrooms are low calorie food with very minute fat content having potent antioxidants that can be valuable as a dietary supplement in favor of the patients suffering from a majority of disease conditions like Alzheimer’s disease, atherosclerosis, cancer, diabetes mellitus, hypertension, inflammatory conditions, ischaemia, obesity, Parkinsonism and so on [11-15]....

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Journal Article
TL;DR: In this paper, the authors investigated the antioxidant activity using different in vitro assays and nitric oxide synthase activation property of crude water soluble polysaccharide from P ostreatus.
Abstract: The aim of this study was to investigate the antioxidant activity using different in vitro assays and nitric oxide synthase activation property of crude water soluble polysaccharide from P. ostreatus. The polysaccharide was isolated by hot water extraction and physico-chemical investigation revealed that it contained high amount of carbohydrate (mostly β-glucan) and low amount of protein and phenolic compounds. EC50 values for scavenging of hydroxyl radical and superoxide radical as well as chelating ability of ferrous ion were 665, 390 and 370 µg/ml respectively. The polysaccharide also showed potential nitric oxide synthase activation properties. This mushroom might be a good source of bioactive compounds.

26 citations


Cites background or result from "Proximate Composition, Free Radical..."

  • ...Similar observations were made earlier where hot water extract of Astreus hygrometricus [43], Ramaria aurea [20], Volvariella volvacea [21], Meripilus gigantium [22] were capable of inducing NOS in in vitro model system....

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  • ...Recent investigations revealed that polysaccharides and extracts of mushrooms had strong antioxidant and NO synthase activation properties [18-24]....

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Journal Article
TL;DR: In this article, the authors tested the Ethanolic fraction from edible mushroom, Pleurotus flabellatus, for total phenol, flavonoid, β-carotene, lycopene and ascorbic acid and in vitro antioxidant activity in terms of DPPH radical scavenging chelating effect of ferrous ion, reducing power and total antioxidant capacity assay.
Abstract: Ethanolic fraction from edible mushroom, Pleurotus flabellatus, was tested for total phenol, flavonoid, β-carotene, lycopene and ascorbic acid and in vitro antioxidant activity in terms of DPPH radical scavenging chelating effect of ferrous ion, reducing power and total antioxidant capacity assay. Findings showed that EC50 values were below 1 mg /ml except DPPH radical scavenging test. The extract exhibited 50% DPPH radical scavenging activity at only 1.8 mg /ml concentration. Estimated putative antioxidant components was in order of ascorbic acid> phenol> flavonoids> β-carotene> lycopene. Result implies that P. flabellatus can be a potential source of natural antioxidant which may be used as food suplement to treat various oxidative stress related diseases.

14 citations