Journal ArticleDOI
Proximity hybridization triggered hybridization chain reaction for label-free electrochemical homogeneous aptasensors.
Xianjiu Liao,Caiyi Zhang,Jeremiah Ong'achwa Machuki,Xiaoqing Wen,Duankai Chen,Qianli Tang,Fenglei Gao +6 more
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TLDR
A label-free homogeneous electrochemical aptasensor was developed for detection of thrombin based on proximity hybridization triggered hybridization chain reaction induced G-quadruplex formation as mentioned in this paper.About:
This article is published in Talanta.The article was published on 2021-05-01. It has received 19 citations till now. The article focuses on the topics: Molecular beacon & Aptamer.read more
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Rapid electrochemical biosensor for sensitive profiling of exosomal microRNA based on multifunctional DNA tetrahedron assisted catalytic hairpin assembly
TL;DR: In this paper, a robust electrochemical biosensor was proposed using multifunctional DNA tetrahedrons assisted catalytic hairpin assembly (MDTs-CHA) for exosomal microRNA (exo-miRNA) analysis.
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Recent Progress in DNA Hybridization Chain Reaction Strategies for Amplified Biosensing.
TL;DR: In this article, the authors summarize the assembly principles of conventional HCR and some novel forms of linear/nonlinear HCR, and a deep discussion is provided about the challenges and future tasks of this field.
Journal ArticleDOI
Recent progress in homogeneous electrochemical sensors and their designs and applications
TL;DR: In this paper , the authors discuss the recent research progress on the design, development and application of homogeneous electrochemical sensors for target analytes from a single signal to dual signal and from single analyte to multiple analytes.
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Current progress in aptamer-based sensing tools for ultra-low level monitoring of Alzheimer's disease biomarkers.
Irfan Rizka Akbar, Mitri Nelsi, Indra Januar Rukmana,Javad Zamanian,ATLAS Collaboration,Zahra Khoshbin,Khalil Abnous,Seyed Mohammad Taghdisi,Hossein Hosseinzadeh,Noor Mohammd Danesh,Noor Mohammd Danesh +8 more
TL;DR: Aptamer-based biosensors have acquired utmost importance in the field of AD healthcare, due to excellent sensitivity and specificity, ease-of-use, cost-effectiveness, portability, and rapid assay time.
Journal ArticleDOI
Current progress in aptamer-based sensing tools for ultra-low level monitoring of Alzheimer's disease biomarkers
TL;DR: Aptamer-based biosensors have acquired utmost importance in the field of AD healthcare, due to excellent sensitivity and specificity, ease-of-use, cost-effectiveness, portability, and rapid assay time as discussed by the authors .
References
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Base-stacking and base-pairing contributions into thermal stability of the DNA double helix
TL;DR: It is found that temperature and salt dependences of the stacking term fully determine the temperature and the salt dependence of DNA stability parameters.
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Nucleic acid helix stability: effects of salt concentration, cation valence and size, and chain length.
Zhi-Jie Tan,Shi-Jie Chen +1 more
TL;DR: This study uses the TBI theory to investigate how the metal ions affect the folding stability of B-DNA helices, and quantitatively evaluates the effects of ion concentration, ion size and valence, and helix length on the helix stability.
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Label-Free and Enzyme-Free Homogeneous Electrochemical Biosensing Strategy Based on Hybridization Chain Reaction: A Facile, Sensitive, and Highly Specific MicroRNA Assay.
TL;DR: The as-proposed label-free and enzyme-free homogeneous electrochemical strategy may become an alternative method for simple, sensitive, and selective miRNA detection, and it has great potential to be applied in miRNA-related clinical diagnostics and biochemical research.
Journal ArticleDOI
A Reversible pH-Driven DNA Nanoswitch Array
Dongsheng Liu,Andreas Bruckbauer,Chris Abell,Shankar Balasubramanian,Dae Joon Kang,David Klenerman,Dejian Zhou +6 more
TL;DR: An array of surface-immobilized proton-fueled DNA nanomachines is reversibly actuated by cycling of the solution pH between 4.5 and 9, producing a conformational change between a four-stranded and a double-Stranded structure, which elongates or shortens the separation distance between the 5' and 3' end of the DNA.
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A novel colorimetric triple-helix molecular switch aptasensor for ultrasensitive detection of tetracycline
Mohammad Ramezani,Noor Mohammad Danesh,Parirokh Lavaee,Khalil Abnous,Seyed Mohammad Taghdisi +4 more
TL;DR: A colorimetric aptasensor was designed for sensitive, selective and fast detection of tetracycline based on triple-helix molecular switch (THMS) and gold nanoparticles (AuNPs) and was successfully applied to detect tetrACYcline in serum and milk.