Open AccessJournal Article
Psammomatous melanotic schwannoma
Reads0
Chats0
TLDR
In this paper, the authors present histological and immunohistochemical findings in two cases of the tumor arising in the spinal nerve roots region at a 56-year-old woman and a 58-year old man.Abstract:
Psammomatous melanotic schwannoma is a rare variant of schwannoma. The authors present histological and immunohistochemical findings in two cases of the tumor arising in the spinal nerve roots region at a 56-year-old woman and a 58-year-old man. The latter recurred locally. Microscopically the tumor was composed of polygonal epithelioid or spindle-shaped cells. Some of these cells contained melanin. Small calcifications were dispersed throughout the lesion. Ultrastructural examination of one of these cases revealed nerve sheath origin of the tumor cells and identified premelanosomes and melanosomes within the cytoplasm of neoplastic cells. Histogenesis and relationship of the tumor to Carney complex are discussed.read more
Citations
More filters
Journal ArticleDOI
Pathology of Peripheral Nerve Sheath Tumors: Diagnostic Overview and Update on Selected Diagnostic Problems
TL;DR: Although the diagnosis and classification of most conventional peripheral nerve sheath tumors are relatively straightforward for the experienced observer, yet borderline and difficult-to-classify neoplasms continue to be problematic, this review attempts to provide some useful guidelines for the surgical neuropathologist to help navigate these persistent, challenging problems.
Journal ArticleDOI
Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the Carney complex
Lawrence S. Kirschner,Fabiano Sandrini,Juahdi Monbo,Jing-Ping Lin,J. Aidan Carney,Constantine A. Stratakis +5 more
TL;DR: It is concluded that genetic heterogeneity exists in CNC; and all of the CNC alleles on 17q are functionally null mutations of PRKAR1A, the first human disease recognized to be caused by mutations of the PKA holoenzyme.
Journal ArticleDOI
Tumors of the meninges: proposed modifications of the World Health Organization classification.
TL;DR: The proposed modifications of the WHO classification of meningiomas represent a compromise between the pathologist's need for a complete morphologic exposition and the clinician's desire for a concise classification of therapeutic and prognostic significance.
Journal ArticleDOI
Spinal melanotic schwannoma: a tumour with poor prognosis.
TL;DR: To clarify the prognosis of melanotic schwannoma, this is a rare tumour which is generally considered as a benign lesion, reported in many cases with a short follow‐up only.
Journal ArticleDOI
Genetic insights into familial tumors of the nervous system
TL;DR: The identification of genes associated with familial cancer syndromes has in some families enabled a “molecular diagnosis” that complements clinical assessment and allows directed cancer surveillance for those individuals determined to be at‐risk for disease.