Psychedelics for Brain Injury: A Mini-Review
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"Psychedelics for Brain Injury: A Mi..." refers background in this paper
...Presence of THC on urine drug screen is associated with decreased mortality in adult patients sustaining TBI (65)....
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...Instead, careful regulation of the inflammatory response, Abbreviations: 5HTR, 5-HT receptors; ALS, Amyotrophic lateral sclerosis; DMN, Default-mode network; DMT, N,N-Dimethyltryptamine; DOI, 2,5-dimethoxy-4iodoamphetamine; DOC, Disorder of consciousness; EEG, Electroencephalogram; fMRI, Functional magnetic resonance imaging; IL, Interleukin; LSD, Lysergic acid diethyl amide; LZC, Lempel-Ziv complexity; MAOI, Monoamine oxidase inhibitor; MCAO, Middle cerebral artery occlusion; MDMA, 3,4- methylenedioxymethamphetamine; MVF, Mirror visual feedback therapy; NFAT, Nuclear factor of activated T-cells; REM, Rapid eye movement sleep; S1R, Sigma-1 receptor; TBI, Traumatic brain injury; THC, Tetrahydrocannabinol; TLR, Toll-like receptor; TNF, Tumor necrosis factor; SOD, Superoxide dismutase. rather than blunt reduction of the response, or “single-target” approaches, is critical to improved outcomes....
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...There is already mixed evidence to suggest the use of non-classical psychedelics ketamine (63, 64), as well as tetrahydrocannabinol (THC) (65, 66) and cannabidiol (67, 68), as neuroprotectants after TBI and stroke....
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12,729 citations
"Psychedelics for Brain Injury: A Mi..." refers background in this paper
...In patients <12 months post stroke, MVF therapy enhances functional recovery of lower limbs and hands (43, 44)....
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3,053 citations
"Psychedelics for Brain Injury: A Mi..." refers background in this paper
...Though many factors are implicated in hippocampal neurogenesis, one of the most important is 5HTR stimulation (33, 34)....
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2,024 citations
"Psychedelics for Brain Injury: A Mi..." refers background in this paper
...While hippocampal neurogenesis after TBI is implicated in improved cognition, relief from depressed mood, and encoding of episodic memory, it is also associated with pro-epileptogenic changes and spatial memory impairment (29, 31, 32)....
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1,285 citations
"Psychedelics for Brain Injury: A Mi..." refers background in this paper
...Though these are a novel class of drugs deserving close study, more data are necessary to prove their efficacy for treatment of brain injury, as historically many compounds have seemed promising in vitro, including likely hundreds of compounds thought to facilitate neuroplasticity and neuroprotection, but have not borne out in clinical trials (61, 62)....
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