Psychotomimetic symptoms after a moderate dose of a synthetic cannabinoid (JWH-018) : implications for psychosis
Eef L. Theunissen,J. Reckweg,Nadia R P W Hutten,Kim P. C. Kuypers,Stefan W. Toennes,Merja A. Neukamm,Sebastian Halter,Johannes G. Ramaekers +7 more
Reads0
Chats0
TLDR
In this paper, the psychotomimetic effects of a moderate dose of synthetic cannabinoids (JWH-018) were assessed in healthy participants with no history of mental illness, which confirmed that synthetic cannabinoids pose a serious risk for public health.Abstract:
Synthetic cannabinoids (SCs) are the largest class of novel psychoactive substances (NPS) and are associated with an increased risk of overdosing and adverse events such as psychosis. JWH-018 is one of the earliest SCs and still widely available in large parts of the world. Controlled studies to assess the safety and behavioural profiles of SCs are extremely scarce. The current study was designed to assess the psychotomimetic effects of a moderate dose of JWH-018. Twenty-four healthy participants (10 males, 14 females) entered a placebo-controlled, double blind, within-subjects trial and inhaled vapour of placebo or 75μg/kg bodyweight JWH-018. To ascertain a minimum level of intoxication, a booster dose of JWH-018 was administered on an as-needed basis. The average dose of JWH-018 administered was 5.52 mg. Subjective high, dissociative states (CADSS), psychedelic symptoms (Bowdle), mood (POMS) and cannabis reinforcement (SCRQ) were assessed within a 4.5-h time window after drug administration. JWH-018 caused psychedelic effects, such as altered internal and external perception, and dissociative effects, such as amnesia, derealisation and depersonalisation and induced feelings of confusion. Overall, these findings suggest that a moderate dose of JWH-018 induces pronounced psychotomimetic symptoms in healthy participants with no history of mental illness, which confirms that SCs pose a serious risk for public health.read more
Citations
More filters
Journal ArticleDOI
The why behind the high: determinants of neurocognition during acute cannabis exposure.
TL;DR: Ramaekers et al. as discussed by the authors reviewed the neural basis of acute cannabis exposure and response variability, and considered the legal, therapeutic and societal implications, and argued that these determinants of the cannabis-induced neurocognitive state should be taken into account when defining and evaluating levels of cannabis impairment.
Journal ArticleDOI
Intoxication by a synthetic cannabinoid (JWH-018) causes cognitive and psychomotor impairment in recreational cannabis users.
Eef L. Theunissen,J. Reckweg,Nadia R P W Hutten,Kim P. C. Kuypers,Stefan W. Toennes,Merja A. Neukamm,Sebastian Halter,Johannes G. Ramaekers +7 more
TL;DR: In this paper, the authors investigated the acute effects of synthetic cannabinoids on cognitive and psychomotor tasks in participants who are demonstrating representative levels of acute intoxication, including motor coordination, attention, memory, speed-accuracy efficiency, and response speed.
Journal ArticleDOI
A Comparison of Acute Neurocognitive and Psychotomimetic Effects of a Synthetic Cannabinoid and Natural Cannabis at Psychotropic Dose Equivalence
TL;DR: It is concluded that psychotropic dose equivalence provides a uniform approach for comparing the neurocognitive and psychotomimetic profiles of CB1 agonists, which can also be applied to other drug classes.
Journal ArticleDOI
Psychomotor performances relevant for driving under the combined effect of ethanol and synthetic cannabinoids: A systematic review
TL;DR: In this paper , the authors conducted a systematic review of the literature to determine whether the acute co-consumption of ethanol and synthetic cannabinoids increases the risk of a motor vehicle collision and affects the psychomotor performances relevant for driving.
Journal ArticleDOI
Cannabis Use in Autism: Reasons for Concern about Risk for Psychosis
TL;DR: Findings support a developmental trajectory between autism and psychosis, as per endocannabinoid system modulation, but such evidence has not received the attention it deserves.
References
More filters
European Monitoring Centre for Drugs and Drug Addiction
TL;DR: The EMCDDA Programme 2, 'Analysis of responses', set out to identify how social reintegration is understood in each Member State and to map the availability of social reIntegration facilities in Member States according to these national perceptions.
Journal ArticleDOI
Cannabinoid receptor localization in brain
TL;DR: The potencies of a series of natural and synthetic cannabinoids as competitors of [3H]CP 55,940 binding correlated closely with their relative potencies in several biological assays, suggesting that the receptor characterized in the in vitro assay is the same receptor that mediates behavioral and pharmacological effects of cannabinoids, including human subjective experience.
Journal ArticleDOI
Adverse health effects of non-medical cannabis use
Wayne Hall,Louisa Degenhardt +1 more
TL;DR: The most probable adverse effects include a dependence syndrome, increased risk of motor vehicle crashes, impaired respiratory function, cardiovascular disease, and adverse effects of regular use on adolescent psychosocial development and mental health.
Journal ArticleDOI
The psychotomimetic effects of intravenous Delta-9-tetrahydrocannabinol in healthy individuals: Implications for psychosis
Deepak Cyril D'Souza,Edward Perry,Lisa MacDougall,Yola Ammerman,Thomas B. Cooper,Thomas B. Cooper,Yu-te Wu,Gabriel Braley,Ralitza Gueorguieva,John H. Krystal +9 more
TL;DR: It is indicated that Δ-9-THC produces a broad range of transient symptoms, behaviors, and cognitive deficits in healthy individuals that resemble some aspects of endogenous psychoses and warrant further study of whether brain cannabinoid receptor function contributes to the pathophysiology of psychotic disorders.
Journal ArticleDOI
Adverse effects of cannabis
Wayne Hall,Nadia Solowij +1 more
TL;DR: There is conflicting evidence about many of the effects of cannabis use, so the evidence on the most probable adverse health and psychological consequences of acute and chronic use is summarized.