Pullulan: A novel molecule for biomedical applications.
TL;DR: This review presents elaborated discussion on role of pullulan and its derivatives in various biomedical applications e.g. drug delivery, gene targeting, tissue engineering, vaccination, plasma substitution, chaperone-like activity, medical imaging, insulinotropic activity, pharmaceutical dosages formation, coating, etc.
About: This article is published in Carbohydrate Polymers.The article was published on 2017-09-01. It has received 202 citations till now. The article focuses on the topics: Pullulan & Aureobasidium pullulans.
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TL;DR: The various aspects of the investigation results of the bioactivities of polysaccharides were summarized, including its diversity pharmacological applications, such as immunoregulatory, anti-tumor,Anti-virus, antioxidation, and hypoglycemic activity, and their application in the treatment of disease are discussed.
687 citations
TL;DR: This review investigates the significant role polysaccharide particles play in functional drug delivery and scrutinizes the methods of synthesizing and constructing functional poly Saccharide particle drug delivery systems that maintain and extend the functionality of the naturalpolysaccharides.
198 citations
TL;DR: In this review, the physical–chemical properties of PLGA, its synthesis, degradation, and conjugation with other polymers or molecules are revised in detail, as well as its applications in drug delivery and regeneration fields.
Abstract: Poly(lactic-co-glycolic) acid (PLGA) is one of the most versatile biomedical polymers, already approved by regulatory authorities to be used in human research and clinics. Due to its valuable characteristics, PLGA can be tailored to acquire desirable features for control bioactive payload or scaffold matrix. Moreover, its chemical modification with other polymers or bioconjugation with molecules may render PLGA with functional properties that make it the Holy Grail among the synthetic polymers to be applied in the biomedical field. In this review, the physical-chemical properties of PLGA, its synthesis, degradation, and conjugation with other polymers or molecules are revised in detail, as well as its applications in drug delivery and regeneration fields. A particular focus is given to successful examples of products already on the market or at the late stages of trials, reinforcing the potential of this polymer in the biomedical field.
191 citations
TL;DR: This review compiles information about biopolymers used as the matrix for the films with nanofillers as the active agents and their possible use within the food industry and food packaging systems.
Abstract: Waste from non-degradable plastics is becoming an increasingly serious problem. Therefore, more and more research focuses on the development of materials with biodegradable properties. Bio-polymers are excellent raw materials for the production of such materials. Bio-based biopolymer films reinforced with nanostructures have become an interesting area of research. Nanocomposite films are a group of materials that mainly consist of bio-based natural (e.g., chitosan, starch) and synthetic (e.g., poly(lactic acid)) polymers and nanofillers (clay, organic, inorganic, or carbon nanostructures), with different properties. The interaction between environmentally friendly biopolymers and nanofillers leads to the improved functionality of nanocomposite materials. Depending on the properties of nanofillers, new or improved properties of nanocomposites can be obtained such as: barrier properties, improved mechanical strength, antimicrobial, and antioxidant properties or thermal stability. This review compiles information about biopolymers used as the matrix for the films with nanofillers as the active agents. Particular emphasis has been placed on the influence of nanofillers on functional properties of biopolymer films and their possible use within the food industry and food packaging systems. The possible applications of those nanocomposite films within other industries (medicine, drug and chemical industry, tissue engineering) is also briefly summarized.
172 citations
Cites background from "Pullulan: A novel molecule for biom..."
...Pullulan is a neutral polysaccharide obtained from the fermentation medium of the fungus-like yeast Aureobasidium pullulans [25]....
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TL;DR: Some significant techniques, including sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), infrared (IR) spectra, fluorescence spectroscopy, nuclear magnetic resonance (NMR), UV-vis spectroscope, circular dichroism (CD), and differential scanning calorimetry (DSC) are addressed.
140 citations
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