Pullulan-based dissolving microneedle arrays for enhanced transdermal delivery of small and large biomolecules.
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TLDR
For the first time, the preparation and characterisation of a DMN system from the carbohydrate biopolymer, pullulan (PL) is reported, demonstrating that PL DMNs may serve as a promising tool for efficient transdermal drug delivery.About:
This article is published in International Journal of Biological Macromolecules.The article was published on 2020-03-01 and is currently open access. It has received 95 citations till now. The article focuses on the topics: Transdermal & Pullulan.read more
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Journal ArticleDOI
Current trends in polymer microneedle for transdermal drug delivery.
Khater Ahmed Saeed AL-Japairai,Syed Mahmood,Samah Hamed Almurisi,Jayarama Reddy Venugopal,Ayah Rebhi Hilles,Motia Azmana,Subashini Raman +6 more
TL;DR: Graphical abstract Polymer microneedle promotes the delivery of chemical and biological drugs through the skin through its role in cell reprograming and wound healing.
Journal ArticleDOI
Enhancement strategies for transdermal drug delivery systems: current trends and applications.
TL;DR: In this paper, the authors reviewed current trends and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of Transdermal drug delivery systems and enhancement strategies.
Journal ArticleDOI
Hollow microneedles: A perspective in biomedical applications.
Álvaro Cárcamo-Martínez,Brónach Mallon,Juan Domínguez-Robles,Lalitkumar K. Vora,Qonita Kurnia Anjani,Ryan F. Donnelly +5 more
TL;DR: In this article, a review on hollow microneedles, materials and methods for their fabrication as well as their application in drug delivery, vaccine delivery and monitoring purposes is presented.
Journal ArticleDOI
Microneedle Mediated Transdermal Delivery of Protein, Peptide and Antibody Based Therapeutics: Current Status and Future Considerations
TL;DR: The true potential of MNs as a drug delivery device for biopharmaceuticals will not only rely on acceptance from prescribers, patients and the regulatory authorities, but the ability to upscale MN manufacture in a cost-effective manner and the long term safety of MN application.
Journal ArticleDOI
Biodegradable microneedles fabricated with carbohydrates and proteins: Revolutionary approach for transdermal drug delivery.
Neha Dabholkar,Srividya Gorantla,Tejashree Waghule,Vamshi Krishna Rapalli,Avinash Kothuru,Sanket Goel,Gautam Singhvi +6 more
TL;DR: In this article, a review of various polysaccharides and polypeptide based biomaterials that are used to fabricate biodegradable microneedles is presented.
References
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Journal ArticleDOI
Dissolving microneedles for transdermal drug delivery.
TL;DR: It is concluded that dissolving microneedles can be designed to gently encapsulate molecules, insert into skin, and enable bolus or sustained release delivery and leave behind no biohazardous sharp medical waste.
Journal ArticleDOI
Hydrogel‐Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery
Ryan F. Donnelly,Thakur Raghu Raj Singh,Martin J. Garland,Katarzyna Migalska,Rita Majithiya,Cian M. McCrudden,Prashant Laxman Kole,Tuan Mazlelaa Tuan Mahmood,Helen O. McCarthy,A. David Woolfson +9 more
TL;DR: This technology has the potential to overcome the limitations of conventional microneedle designs and greatly increase the range of the type of drug that is deliverable transdermally, with ensuing benefits for industry, healthcare providers and, ultimately, patients.
Journal ArticleDOI
The pig as an experimental animal model of percutaneous permeation in man: qualitative and quantitative observations--an overview.
Gad A. Simon,Howard I. Maibach +1 more
TL;DR: Anatomical, physiological and biochemical similarities are cited and various uses of the pig as a model for man in the investigation of skin permeation are reviewed, including several isolated organ models.
Book ChapterDOI
Microneedle-based vaccines
TL;DR: Overall, these studies suggest that microneedles may provide a safe and effective method of delivering vaccines with the possible added attributes of requiring lower vaccine doses, permitting low-cost manufacturing, and enabling simple distribution and administration.
Journal ArticleDOI
A proposed model membrane and test method for microneedle insertion studies.
Eneko Larrañeta,Jessica Moore,Eva M. Vicente-Pérez,Patricia González-Vázquez,Rebecca E. M. Lutton,A. David Woolfson,Ryan F. Donnelly +6 more
TL;DR: A commercial polymeric film (Parafilm M®, a blend of a hydrocarbon wax and a polyolefin) was evaluated as a model membrane for microneedle (MN) insertion studies as discussed by the authors.