Pulmonary carcinosarcoma initially presenting as invasive aspergillosis: a case report of previously unreported combination
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TLDR
A case of primary carcinosarcoma of the lung concurrently occurring with invasive pulmonary aspergillosis in a 66-year old patient is described.Abstract:
Carcinosarcoma of the lung is a malignant tumor composed of a mixture of carcinoma and sarcoma elements. The carcinomatous component is most commonly squamous followed by adenocarcinoma. The sarcomatous component commonly comprises the bulk of the tumor and shows poorly differentiated spindle cell features. Foci of differentiated sarcomatous elements such as chondrosarcoma and osteosarcoma may be seen. Aspergillus pneumonia is the most common form of invasive aspergillosis and occurs mainly in patients with malignancy, immunocompromizing or debilitating diseases. Patients with Aspergillus pneumonia present with fever, cough, chest pain and occasionally hemoptysis. Tissue examination is the most reliable method for diagnosis, and mortality rate is high. We describe a case of primary carcinosarcoma of the lung concurrently occurring with invasive pulmonary aspergillosis in a 66-year old patient.read more
Citations
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Application of flexible bronchoscopy in inhalation lung injury
Chong Bai,Haidong Huang,Xiao-peng Yao,Shihui Zhu,Bing Li,Jingqing Hang,Wei Zhang,Paul Zarogoulidis,Paul Zarogoulidis,Andreas Gschwendtner,Konstantinos Zarogoulidis,Qiang Li,Michael Simoff +12 more
TL;DR: The use of flexible bronchoscopy has great value in the diagnosis of inhalational injury without any complications and its use should be incorporated into clinical practice.
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Two cases of endobronchial carcinoid masked by superimposed aspergillosis: a review of the literature of primary lung cancers associated with Aspergillus
TL;DR: 2 cases of endobronchial pulmonary carcinoid tumor with superimposed Aspergillus colonization are described, both of which have the possibility of "scar carcinoma."
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Pulmonary carcinosarcoma with heterologous component: report of two cases with literature review
TL;DR: Two cases of carcinosarcoma are reported in a 68-year-old patient and a 78-year old patient explored for lung masses, consisting in adenosquamous carcinoma with osteosarcomA in one case and adenocarcinoma with chondrosarcomas in the other case.
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Extraskeletal myxoid chondrosarcoma in the lung: asymptomatic lung mass with severe anemia
TL;DR: A 51-year-old Asian female initially manifested with signs of severe anemia who presented with a lung mass unrelated to pleura that was morphologically typical EMC, with strong immunoreactivity for vimentin and NSE after resection, and the anemia was cured.
References
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Carcinosarcomas of the lung: a clinicopathologic study of 66 patients.
TL;DR: The histologic differences between these two types of tumor suggest that they may be different entities with similar behavior, but additional studies are warranted to investigate this hypothesis.
Journal ArticleDOI
Carcinosarcoma of the lung: Mayo Clinic experience and response to chemotherapy.
TL;DR: Pulmonary resection with curative intent was performed in 15 of 17 patients; however, only 4 patients were alive at 6, 8, 28, and 39 months, respectively, postoperatively, and the median survival was 1 year.
Journal ArticleDOI
p53 and K-ras Mutational Genotyping in Pulmonary Carcinosarcoma, Spindle Cell Carcinoma, and Pulmonary Blastoma: Implications for Histogenesis
TL;DR: Monoclonal histogenesis from a single totipotential cell in a subset of these neoplasms was supported by the finding of p53 overexpression and identical p53 mutational genotype in both the epithelial and spindle elements of the tumors.
Journal ArticleDOI
Carcinosarcoma and spindle cell carcinoma of the lung. Clinicopathologic and immunohistochemical studies.
Teruyoshi Ishida,Masahiro Tateishi,Satoshi Kaneko,Tokujiro Yano,Tetsuya Mitsudomi,Keizo Sugimachi,Nobuyuki Hara,Mitsuo Ohta +7 more
TL;DR: It is wished to emphasize that a distinction of sarcomatous components should be made with regard to assessing the prognosis of pulmonary carcinoma with sarcoma-like lesions, because the fibromatous sarcomas were found to relate to a longer survival time for the patients.
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