Pulmonary epithelioid haemangioendothelioma in 21 patients, including three with partial spontaneous regression
Masanori Kitaichi,Sonoko Nagai,Koichi Nishimura,Harumi Itoh,Asamoto H,Takateru Izumi,DH Dail +6 more
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This investigation studied the general conditions and prognostic factors of pulmonary epithelioid haemangioendothelioma, which is a rare disease, and three patients demonstrated partial spontaneous regression, and adverse prognostic features were identified.Abstract:
This investigation studied the general conditions and prognostic factors of pulmonary epithelioid haemangioendothelioma (PEH), which is a rare disease. Twenty-one patients were collected throughout Asia by a questionnaire. Age at the detection or onset of symptoms of PEH was 14-64 yrs (mean 44 yrs). Males were more likely to be detected by symptoms (4/8, 50%) than were females (1/13, 8%). Fifteen showed bilateral multiple nodular opacities. Partial spontaneous regression occurred in three asymptomatic patients (one male and two females, all with bilateral multiple nodular opacities) 5, 13 and 15 yrs after detection. Two of the three patients with pleural effusion died within 1 yr, while the 16 patients with no effusion were alive more than 1 yr later (p<0.05). Histologically, two patients with fibrinofibrous pleuritis and extrapleural proliferation of tumour cells died within 2 yrs, while only one of 14 patients lacking such manifestations died within the same period (p<0.05). All three patients without spindle tumour cells survived for 12 yrs after the diagnosis, while all four patients with such cells died during the same period (p<0.05). In conclusion, 21 patients with pulmonary epithelioid haemangioendothelioma were reported, of whom three demonstrated partial spontaneous regression, and adverse prognostic features were identified.read more
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Epithelioid Hemangioendothelioma: An Overview and Update on a Rare Vascular Tumor
TL;DR: Evidence is in favor of radiotherapy which offers local pain control with good tolerance and better quality of life at least at a one-year follow-up in most of cases, and further studies are needed to establish the standard radiation dose to be used for locoregional control of such a complex and extremely rare disease.
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Clinical Patterns and Outcome in Epithelioid Hemangioendothelioma With or Without Pulmonary Involvement: Insights From an Internet Registry in the Study of a Rare Cancer
Kenneth Lau,Malek G. Massad,Cynthia Pollak,Charles M. Rubin,Joannie Yeh,Jing Wang,Guy Edelman,Jenny Yeh,Sunil M. Prasad,Guy L. Weinberg +9 more
TL;DR: A novel staging system with prognostic value for EHE is proposed because Pleural effusion or other signs of uncontained tumor growth, hemoptysis, and osseous involvement of more than two bones implied worse survival than did localized and discrete tumors, regardless of number of organs involved.
Journal ArticleDOI
Prognostic factors and surgical indications of pulmonary epithelioid hemangioendothelioma: a review of the literature.
P. Bagan,Mohammed Hassan,Françoise Le Pimpec Barthes,Séverine Peyrard,R. Souilamas,Claire Danel,Marc Riquet +6 more
TL;DR: Pulmonary epithelioid hemangioendothelioma typically occurs among young patients, and loss of weight, anemia, pulmonary symptoms, and more particularly pleural hemorrhagic effusions were significant factors of poor prognosis.
Journal ArticleDOI
Aggressive form of pleural epithelioid haemangioendothelioma : complete response after chemotherapy
TL;DR: This study describes a case of bilateral pleural epithelioid haemangioendothelioma that extended to the peritoneum that was confirmed by both conventional examination and immunohistochemistry and a complete response was obtained.
Journal ArticleDOI
Pulmonary Epithelioid Hemangioendothelioma: An Unusual Case and a Review of the Literature
Paul Cronin,Douglas A. Arenberg +1 more
TL;DR: In this article, a case of pulmonary epithelioid hemangioendothelioma, previously known as intravascular bronchoalveolar tumor, was described in a 35-year-old woman with an initial diagnosis made by transbronchial biopsy.
References
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Basic and Clinical Biostatistics
TL;DR: Here is absolutely everything medical students need to know about biostatistics and quantitative methods as applied to medicine, clinical practice, and research.
Journal Article
Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma.
TL;DR: The epithelioid hemangioendothelioma (EHE) as discussed by the authors is a type of cancer characterized by a histiocytoid endothelial cell, which grows in small nests or cords and only focally line well-formed vascular channels.
Journal ArticleDOI
Epithelioid hemangioendothelioma and related lesions
TL;DR: The principal clinical, pathologic, and biologic differences among these three lesions of EH of soft tissue, bone, lung, and liver are discussed.