PVA hydrogel properties for biomedical application
01 Oct 2011-Journal of The Mechanical Behavior of Biomedical Materials (J Mech Behav Biomed Mater)-Vol. 4, Iss: 7, pp 1228-1233
TL;DR: Results show that the PVA hydrogel had the same deformation property as prostate tissue, which can be suitable soft tissue substitutes in needle intervention precision or pre-operation planning studies, particularly in the cases of mimicking creatural tissue deformation and analysing video camera images.
Abstract: PVA has been proposed as a promising biomaterial suitable for tissue mimicking, vascular cell culturing and vascular implanting. In this research, a kind of transparent PVA hydrogel has been investigated in order to mimic the creatural soft tissue deformation during mini-invasive surgery with needle intervention, such as brachytherapy. Three kinds of samples with the same composition of 3 g PVA, 17 g de-ionized water, 80 g dimethyl-sulfoxide but different freeze/thaw cycles have been prepared. In order to investigate the structure and properties of polyvinyl alcohol hydrogel, micro-structure, mechanical property and deformation measurement have been conducted. As the SEM image comparison results show, with the increase of freeze/thaw cycles, PVA hydrogel revealed the similar micro-structure to porcine liver tissue. With uniaxial tensile strength test, the above composition with a five freeze/thaw cycle sample resulted in Young's modulus similar to that of porcine liver's property. Through the comparison of needle insertion deformation experiment and the clinical experiment during brachytherapy, results show that the PVA hydrogel had the same deformation property as prostate tissue. These transparent hydrogel phantom materials can be suitable soft tissue substitutes in needle intervention precision or pre-operation planning studies, particularly in the cases of mimicking creatural tissue deformation and analysing video camera images.
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TL;DR: This review critically detail the most common natural and synthetic hydrogel formulations, their designs and their most significant and current biomedical applications.
276 citations
TL;DR: This review highlights recent progress in the design and fabrication of PVA-based hydrogels, including crosslinking and processing techniques, and major challenges and future perspectives in tissue engineering are briefly discussed.
Abstract: Poly (vinyl alcohol) (PVA) is a hydrophilic polymer with excellent biocompatibility and has been applied in various biomedical areas due to its favorable properties. PVA-based hydrogels have been recognized as promising biomaterials and suitable candidates for tissue engineering applications and can be manipulated to act various critical roles. However, due to some disadvantages (i.e., lack of cell-adhesive property), they needs further modification for desired and targeted applications. This review highlights recent progress in the design and fabrication of PVA-based hydrogels, including crosslinking and processing techniques. Finally, major challenges and future perspectives in tissue engineering are briefly discussed.
269 citations
TL;DR: The aim was to offer a systematic overview on the current state concerning the preparation, properties and various applications of biomaterials based on synergistic effect of mixtures between PVA and PVP.
245 citations
TL;DR: This review highlights recent advances in cryogelation techniques and starting materials that can be utilised to synthesise biocompatible and biologically relevant cryogels as well as discussing physicochemical characterisation techniques for these materials.
Abstract: The use of hydrogels as support materials for the growth and proliferation of mammalian cells has been well documented as they closely mimic the gel-like properties - and in some cases also the chemical properties - of the extracellular matrix (ECM), which naturally surrounds the cells of any biological tissue. Macro-porous hydrogels set below the freezing point of the solvent, so-called 'cryogels', have recently gained significant interest in the fields of tissue engineering and in vitro cell culture, thanks to their inherent interconnected macro-porous structure and ease of formation in comparison to other macro-pore forming techniques. This review highlights recent advances in cryogelation techniques and starting materials that can be utilised to synthesise biocompatible and biologically relevant cryogels as well as discussing physicochemical characterisation techniques for these materials. Lastly, emerging trends in the application of cryogels, particularly as three-dimensional ECM mimicking scaffolds for cell culture and tissue engineering, are discussed.
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References
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TL;DR: The composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices are reviewed to identify the most important properties relevant to their biomedical applications.
5,173 citations
"PVA hydrogel properties for biomedi..." refers methods in this paper
...Hoffman has successfully used PVA hydrogels to cultivate living cells, because such hydrogels have large pores and are capable of degradation (Hoffman, 2002)....
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Book•
15 Dec 2001
TL;DR: This renowned work is a guide to the fundamental principles of medical imaging physics, radiation protection and radiation biology, with complex topics presented in the clear and concise manner and style for which these authors are known.
Abstract: This renowned work is derived from the authors' acclaimed national review course ("Physics of Medical Imaging") at the University of California-Davis for radiology residents. The text is a guide to the fundamental principles of medical imaging physics, radiation protection and radiation biology, with complex topics presented in the clear and concise manner and style for which these authors are known. Coverage includes the production, characteristics and interactions of ionizing radiation used in medical imaging and the imaging modalities in which they are used, including radiography, mammography, fluoroscopy, computed tomography and nuclear medicine. Special attention is paid to optimizing patient dose in each of these modalities. Sections of the book address topics common to all forms of diagnostic imaging, including image quality and medical informatics as well as the non-ionizing medical imaging modalities of MRI and ultrasound. The basic science important to nuclear imaging, including the nature and production of radioactivity, internal dosimetry and radiation detection and measurement, are presented clearly and concisely. Current concepts in the fields of radiation biology and radiation protection relevant to medical imaging, and a number of helpful appendices complete this comprehensive textbook. The text is enhanced by numerous full color charts, tables, images and superb illustrations that reinforce central concepts. The book is ideal for medical imaging professionals, and teachers and students in medical physics and biomedical engineering. Radiology residents will find this text especially useful in bolstering their understanding of imaging physics and related topics prior to board exams. Features: new Four-color throughout; new Companion website with fully searchable text and images; basic line drawings help to explain concepts; comprehensive coverage of diagnostic imaging modalities; and superb writing style of the author team helps make a difficult subject approachable and engaging.
1,394 citations
TL;DR: The status of DNA vaccines in poultry, livestock and companion animals is reviewed here and early studies highlight the potential DNA vaccinology offers in veterinary medicine.
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TL;DR: The compressive tangent modulus varied with biomaterial formulation and was found to be statistically strain magnitude and rate dependent and shear mechanical properties of a novel PVA hydrogel were characterized.
600 citations
"PVA hydrogel properties for biomedi..." refers background in this paper
...…for repairing and regenerating a wide variety of tissues and organs (Woerly et al., 1996), (Hubbell, 1998), including arterial phantom (Chu and Rutt, 1997), heart valves (Jiang et al., 2004), corneal implants (Vijayasekaran et al., 1998), and cartilage tissue substitutes (Stammen et al., 2001)....
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TL;DR: Poly(vinyl alcohol) cryogel, PVA-C, is presented as a tissue-mimicking material, suitable for application in magnetic resonance (MR) imaging and ultrasound imaging, and applications in an anthropomorphic brain phantom, a multi-volume stenosed vessel phantom and breast biopsy phantoms are presented.
Abstract: Poly(vinyl alcohol) cryogel, PVA-C, is presented as a tissue-mimicking material, suitable for application in magnetic resonance (MR) imaging and ultrasound imaging. A 10% by weight poly(vinyl alcohol) in water solution was used to form PVA-C, which is solidified through a freeze-thaw process. The number of freeze-thaw cycles affects the properties of the material. The ultrasound and MR imaging characteristics were investigated using cylindrical samples of PVA-C. The speed of sound was found to range from 1520 to 1540 m s(-1), and the attenuation coefficients were in the range of 0.075-0.28 dB (cm MHz)(-1). T1 and T2 relaxation values were found to be 718-1034 ms and 108-175 ms, respectively. We also present applications of this material in an anthropomorphic brain phantom, a multi-volume stenosed vessel phantom and breast biopsy phantoms. Some suggestions are made for how best to handle this material in the phantom design and development process.
405 citations