Open AccessJournal Article
Pyran Copolymer as an Effective Adjuvant to Chemotherapy against a Murine Leukemia and Solid Tumor
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TLDR
Pyran (divinyl ether-maleic anhydride) copolymer (NSC 46015) is a polyanion with interferon-inducing and macrophage-stimulating properties, and therefore it has been studied as a possible antitumor agent.Abstract:
Summary Pyran (divinyl ether-maleic anhydride) copolymer (NSC 46015) is a polyanion with interferon-inducing and macrophage-stimulating properties, and therefore it has been studied as a possible antitumor agent. Extensive studies using pyran as an adjuvant to chemotherapy against the LSTRA murine leukemia and the Lewis lung carcinoma were performed. Pyran was effective over a dose range of 0.1 to 100 mg/kg/day. Single and multiple dose schedules were both capable of producing significant numbers of cures or increasing life-span, but pyran was ineffective if used without remission inducing chemotherapy. Various molecular weights of pyran copolymer were compared against NSC 46015 for adjuvant activity as well. In general, NSC 46015 tended to be the most efficacious, but all the pyran sizes that were tested possessed significant activity.read more
Citations
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Synthesis of halogen derivatives of benzo[h]chromene and benzo[a]anthracene with promising antimicrobial activities.
TL;DR: The synthesis of novel 7-(4-halophenyl)-8,9-dihydro-7H-12-oxa-9,11-diaza-benzo[a]anthracene derivatives has been reported and antimicrobial activity was shown for most of the synthesized compounds.
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Natural and synthetic chromenes, fused chromenes, and versatility of dihydrobenzo[h]chromenes in organic synthesis.
Ramendra Pratap,Vishnu Ji Ram +1 more
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Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agents.
TL;DR: A simple, clean, environmentally benign route to the synthesis of 2-amino-chromenes is described using K2CO3 as a green catalyst in water under microwave irradiation, implying a convenient route avoiding the usage of hazardous organic solvents and organic bases.
Journal ArticleDOI
DBU: a highly efficient catalyst for one-pot synthesis of substituted 3,4-dihydropyrano[3,2-c]chromenes, dihydropyrano[4,3-b]pyranes, 2-amino-4H-benzo[h]chromenes and 2-amino-4H benzo[g]chromenes in aqueous medium
TL;DR: In this paper, the authors reported DBU catalyzed one-pot synthesis of 3,4-dihydropyrano[3,2-c]chromenes, dihydropyrane[4,3-b]pyranes, 2-amino-4H-benzo[h]chromene and 2-AMino- 4H-bennzo[g]-chromenes from aldehydes.
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Homogeneous and heterogeneous catalysts for multicomponent reactions
TL;DR: In this paper, a review of catalyzed multicomponent reactions performed with acid, base and metal heterogeneous and homogeneous catalysts is presented, and relevant products that can be obtained and their interest for industrial applications are presented.
References
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Journal ArticleDOI
Induction of Circulating Interferon by Synthetic Anionic Polymers of Known Composition
TL;DR: This communication confirms the findings, characterizes this antiviral activity appearing in sera of mice injected with synthetic anionic copolymers of defined composition, identifies it as interferon, and explores certain of the structural requirements forCopolymers to act as Interferon inducers.
Journal ArticleDOI
Induction of macrophage-mediated tumor-cell cytotoxicity by pyran copolymer.
Journal ArticleDOI
Interferon-stimulating and in vivo antiviral effects of various synthetic anionic polymers.
TL;DR: Factors other than interferon may be responsible for part of the antiviral protection observed with the carboxylate copolymer, which induced prolonged protection against lethal Mengo virus infection in the mouse.
Journal Article
Augmentation of chemotherapeutically induced remission of a murine leukemia by a chemical immunoadjuvant.
TL;DR: The administration of chemical immunostimulator was effective at any time during 1,3-bis(2-chloroethyl)-l-nitrosourea-induced remission and low doses of the chemicals were as effective as higher doses in evoking this synergistic response.
Journal Article
Combined chemoimmunostimulation therapy against murine leukemia.
TL;DR: The effect of combining chemotherapy and Immunostimulation against a murine lymphoid leukemic line designated as LSTRA was investigated and a high percentage of long-term survivors occurred in contrast to the groups of animals treated with immunostimulants or drug alone.
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