Pyrimidine derivatives as antagonists of pteroylglutamic acid.
G H Hitchings,G B Elion +1 more
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This article is published in Journal of Biological Chemistry.The article was published on 1948-06-01 and is currently open access. It has received 143 citations till now.read more
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The purine path to chemotherapy
TL;DR: Research on antimetabolites of nucleic acid purines led to drugs for the treatment of acute leukemia, gout and hyperuricemia, and herpesvirus infections, and for the prevention of organ transplant rejection.
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Dihydrofolate reductase as a therapeutic target.
TL;DR: Progress has been made recently in understanding the biochemical basis for the selectivity of this drug and the biochemical mechanism (or mechanisms) responsible for the development of resistance to treatment with the drug, which has led to a new generation of DHFR inhibitors that are now in clinical trials.
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The Evolving Role of Chemical Synthesis in Antibacterial Drug Discovery
TL;DR: It is believed that the strategic application of modern chemical synthesis to antibacterial drug discovery must play a critical role if a crisis of global proportions is to be averted.
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The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery.
TL;DR: The current knowledge of the structure and mechanism of each enzyme in the bacterial folic acid biosynthesis pathway from GTP to dihydrofolate is reviewed and conclusions regarding the potential of each enzymes as a target for therapeutic intervention are drawn.