Journal ArticleDOI
QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients
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TLDR
Antipsychotic drugs cause QTc lengthening in a dose-related manner, and risks are substantially higher for thioridazine and droperidol, which may confer an increased risk of drug-induced arrhythmia.About:
This article is published in The Lancet.The article was published on 2000-03-25. It has received 557 citations till now. The article focuses on the topics: Psychotropic drug & Thioridazine.read more
Citations
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PRACTICE GUIDELINE FOR THE Treatment of Patients With Major Depressive Disorder
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Atypical Antipsychotic Drugs and the Risk of Sudden Cardiac Death
TL;DR: Current users of typical and of atypical antipsychotic drugs had a similar, dose-related increased risk of sudden cardiac death.
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Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder
Lakshmi N. Yatham,Sidney H. Kennedy,Sagar V. Parikh,Ayal Schaffer,David J. Bond,Benicio N. Frey,Verinder Sharma,Benjamin I. Goldstein,Soham Rej,Serge Beaulieu,Martin Alda,Glenda MacQueen,Roumen Milev,Arun V. Ravindran,Claire O'Donovan,Diane McIntosh,Raymond W. Lam,Gustavo Vazquez,Flávio Kapczinski,Roger S. McIntyre,Jan Marie Kozicky,Shigenobu Kanba,Beny Lafer,Trisha Suppes,Joseph R. Calabrese,Eduard Vieta,Gin S Malhi,Robert M. Post,Michael Berk +28 more
TL;DR: These 2018 CANMAT and ISBD Bipolar Treatment Guidelines represent the significant advances in the field since the last full edition was published in 2005, including updates to diagnosis and management as well as new research into pharmacological and psychological treatments.
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The 2009 Schizophrenia PORT Psychopharmacological Treatment Recommendations and Summary Statements
Robert W. Buchanan,Julie Kreyenbuhl,Julie Kreyenbuhl,Deanna L. Kelly,Jason M. Noel,Douglas L. Boggs,Bernard A. Fischer,Seth Himelhoch,Beverly Fang,Eunice Peterson,Patrick R. Aquino,William R. Keller +11 more
TL;DR: An extensive literature review was conducted to determine whether the current psychopharmacological treatment recommendations required revision and whether there was sufficient evidence to warrant new treatment recommendations for prespecified outcomes of interest.
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Assessment and management of behavioral and psychological symptoms of dementia
TL;DR: The paradigm shift needed to fully institute tailored treatments for people and families dealing with these symptoms in the community is discussed and non-pharmacologic approaches with the strongest evidence base involve family care giver interventions are discussed.
References
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Journal ArticleDOI
QT dispersion: an indication of arrhythmia risk in patients with long QT intervals.
TL;DR: In patients with prolonged QT intervals, QT dispersion distinguished between those with ventricular arrhythmias and those without, which supports the hypothesis that Qt dispersion reflects spatial differences in myocardial recovery time.
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Qt dispersion and sudden unexpected death in chronic heart failure
TL;DR: The association of increased QT dispersion with sudden death suggests that patients at high risk of such death could be identified by means of this simple, reproducible test.
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QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest.
TL;DR: Data indicate that in patients without intraventricular conduction defects and cardiac dysfunction, QTc prolongation measured from the standard electrocardiogram is a risk factor for sudden death independent of age, history of myocardial infarction, heart rate, and drug use.
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Precordial QT interval dispersion as a marker of torsade de pointes. Disparate effects of class Ia antiarrhythmic drugs and amiodarone.
TL;DR: An increase in regional QT interval dispersion during class la antiarrhythmic drug therapy is associated with torsade de pointes, which may explain its apparent safe use in patients with a history of class Ia drug-induced torsades de pointe.
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Mortality in a Cohort of Patients with Schizophrenia: A Record Linkage Study*:
Stephen C. Newman,Roger C. Bland +1 more
TL;DR: It is estimated that those who suffer from schizophrenia have a life expectancy which is approximately 20% shorter than that of the general population, and research demonstrating an increased risk of mortality associated with schizophrenia is extended to specific causes of death.
Related Papers (5)
Antipsychotic drugs : Prolonged QTc interval, torsade de pointes, and sudden death
Antipsychotic-Related QTc Prolongation, Torsade de Pointes and Sudden Death
Peter M. Haddad,Ian M. Anderson +1 more